External Oblique Intercostal Plane Block for Liver Transplantation Donors

Not Applicable

Completed

• Conditions: Liver Transplantation; Donor; Postoperative Pain
• Interventions: Other: Subcostal transversus abdominis plane block; Other: External oblique intercostal plane block

• Registration Number: NCT05890079
• Lead Sponsor: Istinye University

Brief Summary

Postoperative pain management is one of the important factors to improve rehabilitation and enhance recovery. External oblique intercostal plane block may be used for abdominal wall analgesia to provide effective analgesia for abdominal surgery. The aim of this study is to investigate the postoperative analgesic efficacy of external oblique intercostal plane block and subcostal transversus abdominis plane block in living liver donors.

Researchers will compare the external oblique intercostal plane block group with subcostal transversus abdominis plane block to see if the external oblique intercostal plane block is effective for postoperative analgesia in living liver donors.

Detailed Description

Patients scheduled for living donor hepatectomy will be separated into 2 groups: Subcostal Transversus Abdominis Plane Block Group and External Oblique Intercostal Plane Block Group. Patients in Subcostal Transversus Abdominis Plane Block will be performed subcostal transversus plane block at the end of the surgery and after skin closure and received patient controlled analgesia with morphine for postoperative analgesia. Patients in External Oblique Intercostal Plane Block Group will be performed bilateral External Oblique Intercostal Plane Block at the end of the surgery and after skin closure and received patient controlled analgesia with morphine for postoperative analgesia. Morphine consumption for first postoperative 24 hours, visual analog scale scores, time to need for first rescue analgesia, amount of rescue analgesic drug, incidence of postoperative nausea and vomiting will be recorded.

Study Timeline

• Status Verified: 2023-05
• Study Start: 2023-05-08
• Study First Submitted: 2023-05-25
• Study First Submitted QC: 2023-05-25
• Study First Posted: 2023-06-06
• Primary Completion: 2023-12-14
• Study Completion: 2024-01-17
• Last Update Submitted: 2024-03-18
• Last Update Posted: 2024-03-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Age between 18 and 75 years
• Patients with American Society of Anesthesiology (ASA) physical status I-II
• Patients scheduled for a living donor hepatectomy

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Exclusion Criteria

• Allergy to local anesthetics
• Coagulopathy
• Skin infection at the block area
• Advanced renal failure
• Chronic pain syndromes
• Alcohol or drug abuse
• Psychiatric disorders

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Subcostal transversus abdominis plane block group	Subcostal transversus abdominis plane block	The patients in subcostal transversus abdominis plane block group will be received subcostal transversus abdominis plane block and patient controlled analgesia with morphine for postoperative analgesia
External oblique intercostal plane block group	External oblique intercostal plane block	The patients in External oblique intercostal plane block group will be received external oblique intercostal plane block and patient controlled analgesia with morphine for postoperative analgesia

Primary Outcome Measures

Name	Time	Method
Morphine consumption	Postoperative 24 hours	The amount of morphine required by the patient and given by the device will be recorded for the first 24 hours.

Secondary Outcome Measures

Name	Time	Method
Postoperative visual analog scale scores	Postoperative 24 hours	Postoperative pain will be assessed using a visual analog scale (VAS) (from 0 = no pain to 10 = maximum possible pain) for the first 24 hours.
Rescue analgesic drug consumption	postoperative 24 hours	The amount of rescue analgesic in mg required by the patient will be recorded for the first 24 hours.
Incidence of postoperative nausea and vomiting	postoperative 24 hours	Number of patients developing postoperative nausea and vomiting will be recorded for the first 24 hours

Trial Locations

Locations (1)

Istinye University Hospital; 🇹🇷 Istanbul, Turkey