Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease

Not Applicable

• Conditions: Aortic Valve Stenosis; Coronary Disease
• Interventions: Other: DSCT, TTE

• Registration Number: NCT00767013
• Lead Sponsor: Luzerner Kantonsspital

Brief Summary

We sought to determine whether the dual-source computed tomography assessment of aortic valve stenosis and coronary artery disease is equivalent to or even better than conventional invasive coronary angiography and transthoracic echocardiography.

Detailed Description

Until now invasive coronary angiography has established itself for the assessment of symptomatic aortic valve stenosis. Literature shows a good correlation between MSCT, MRI, TTE and TEE for evaluating the severity of the aortic valve stenosis.

The dual-source computed tomography (DSCT) is capable of assessing coronary arteries with a high sensitivity and specificity in term of relevant stenosis (\>50%), due to its excellent spatial and temporal resolution. This study includes the assessment of patients with symptomatic valve stenosis. The severity of the aortic valve stenosis is being assessed by DSCT and TTE. Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. We examine the correlation between DSCT on one side and either TTE or invasive coronary angiography on the other.

Study Timeline

• Study Start: 2007-05
• Study First Submitted: 2008-10-03
• Study First Submitted QC: 2008-10-03
• Study First Posted: 2008-10-06
• Status Verified: 2013-04
• Last Update Submitted: 2013-04-16
• Last Update Posted: 2013-04-17
• Primary Completion: 2013-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• Patients with aortic valve disease who were scheduled to undergo cardiac surgery

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Exclusion Criteria

• Hemodynamic instability
• Renal insufficiency (serum creatinine level > 133umol/L)
• Known allergy to iodinated contrast agents
• Non-treated hyperthyreosis

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
AVS, CAD	DSCT, TTE	DSCT

Primary Outcome Measures

Name	Time	Method
Quality of cardiac imaging in computed tomography	After comparison of imaging measurements

Trial Locations

Locations (1)

Luzerner Kantonsspital, Department of Cardiology; 🇨🇭 Lucerne, Luzern, Switzerland