Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease: Dual-source Computed Tomography Compared With Invasive Coronary Angiography and Transthoracic Echocardiography
试验速览
- 阶段
- 不适用
- 入组人数
- 65
- 试验地点
- 2
- 主要终点
- Quality of cardiac imaging in computed tomography
研究概览
简要总结
We sought to determine whether the dual-source computed tomography assessment of aortic valve stenosis and coronary artery disease is equivalent to or even better than conventional invasive coronary angiography and transthoracic echocardiography.
详细描述
Until now invasive coronary angiography has established itself for the assessment of symptomatic aortic valve stenosis. Literature shows a good correlation between MSCT, MRI, TTE and TEE for evaluating the severity of the aortic valve stenosis.
The dual-source computed tomography (DSCT) is capable of assessing coronary arteries with a high sensitivity and specificity in term of relevant stenosis (>50%), due to its excellent spatial and temporal resolution. This study includes the assessment of patients with symptomatic valve stenosis. The severity of the aortic valve stenosis is being assessed by DSCT and TTE. Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. We examine the correlation between DSCT on one side and either TTE or invasive coronary angiography on the other.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with aortic valve disease who were scheduled to undergo cardiac surgery
排除标准
- •Hemodynamic instability
- •Renal insufficiency (serum creatinine level > 133umol/L)
- •Known allergy to iodinated contrast agents
- •Non-treated hyperthyreosis
研究组 & 干预措施
AVS, CAD
DSCT
干预措施: DSCT, TTE (Other)
结局指标
主要结局
Quality of cardiac imaging in computed tomography
时间窗: After comparison of imaging measurements
次要结局
未报告次要终点
研究者
Prof. Paul Erne
Prof. Paul Erne
Luzerner Kantonsspital