A randomised controlled trial of the effect of angiotensin-converting enzyme inhibitors on pulmonary regurgitation, biventricular volume, mass and function, integrated cardiopulmonary exercise and cardiac autonomic reflexes late after Tetralogy of Fallot repair. The APPROPRIATE study (Ace inhibitors for PRevention Of Pulmonary Regurgitation In Adults with TEtralogy)

British Heart Foundation (UK)0 个研究点目标入组 60 人开始时间: 2005年8月8日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•All patients with repaired Tetralogy of Fallot and moderate or more pulmonary regurgitant fraction.

•1. Known allergy or hypersensitivity to ACE-inhibitors
•2. History of coronary artery disease
•3. Pulmonary stenosis more than mild
•4. Unable to undertake Cardiovascular Magnetic Resonance (permanent pacemaker, electrical device etc.)
•5. Renal failure, assessed from patient?s clinical notes and baseline biochemistry check.
•6. Ongoing ACE-inhibitor therapy
•7. Pregnancy/breastfeeding/planning to conceive during participation
•8. Systolic blood pressure less than 90 mmHg
•9. Hyperkaliemia (K+ levels more than 5.5 mEq/l)
•10. Refusal to give informed consent

发起方

British Heart Foundation (UK)