To understand usage pattern, and effectiveness of sacubitril/valsartan in heart failure
Not Applicable
- Conditions
- Health Condition 1: I462- Cardiac arrest due to underlying cardiac condition
- Registration Number
- CTRI/2023/10/058403
- Lead Sponsor
- Dr Reddys Laboratories Ltd
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Heart failure Patients who have been prescribed with CIDMUS and ejection fraction (EF) value are reported at baseline.
2.Patients of either sex =18 years of age
Exclusion Criteria
Patients for whom EF value is not reported at baseline
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To evaluate the usage of sacubitril/valsartan across different <br/ ><br>ranges of EF (=40%, 41-49%, =50%) – signifying HF with <br/ ><br>reduced EF (HFrEF), HF with moderately reduced EF <br/ ><br>(HFmrEF), & HF with preserved EF (HFpEF), respectively. <br/ ><br> <br/ ><br>2.To understand baseline demographics – patients’ age, gender, <br/ ><br>body mass index (BMI), systolic blood pressure (SBP), <br/ ><br>diastolic blood pressure (DBP), comorbid conditions and <br/ ><br>concomitant medications like beta blocker [BB], <br/ ><br>mineralocorticoid receptor antagonist [MRA], Sodium-glucose cotransporter-2 [SGLT2] inhibitors and <br/ ><br>combinations) as monotherapy and/or combination therapy in <br/ ><br>HF patients on sacubitril/valsartan.Timepoint: 2017 to 2023 <br/ ><br>(Data will be captured for one consecutive follow-up visit from the baseline visit/index <br/ ><br>date)
- Secondary Outcome Measures
Name Time Method •The effect of CIDMUS on change in EF from baseline <br/ ><br>•Change in SBP, & DBP from baseline to follow up visits <br/ ><br>•Change in potassium levels from baseline to follow up visit <br/ ><br>•Average dose & dose titrations of CIDMUS <br/ ><br>Timepoint: 2017 to 2023 <br/ ><br>(Data will be captured for one consecutive follow-up visit from the baseline visit/index <br/ ><br>date)