Causal Associations Between Allergic Rhinitis and Asthma

Completed

• Conditions: Allergic Rhinitis; Asthma

• Registration Number: NCT06668974
• Lead Sponsor: Zhibin Xu

Brief Summary

This study investigates the causal relationship between allergic rhinitis and asthma using a bidirectional two-sample Mendelian randomization approach. Genetic data were derived from UK Biobank for allergic rhinitis and from Finnish biobank for asthma. This analysis aims to clarify the potential causal link between these two conditions.

Detailed Description

This observational study utilizes a bidirectional two-sample Mendelian randomization (MR) analysis to examine the causal association between allergic rhinitis and asthma. The genetic data for allergic rhinitis were obtained from the UK Biobank, encompassing 18,934 cases and 64,595 controls, while asthma data were derived from a Finnish biobank, including 20,629 cases and 135,449 controls. The Mendelian randomization analysis was performed using inverse-variance weighting (IVW), Mendelian randomization-Egger (MR-Egger), and weighted median methods to ensure robust causal inference. Additional tests, such as Cochrane's Q test and Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO), were applied to assess heterogeneity and pleiotropy, enhancing the reliability of the findings. The results are expected to provide insights into the bidirectional causal relationship between allergic rhinitis and asthma, potentially informing future prevention and treatment strategies.

Study Timeline

• Status Verified: 2024-10
• Study Start: 2024-10-01
• Primary Completion: 2024-10-15
• Study Completion: 2024-10-28
• Study First Submitted: 2024-10-30
• Study First Submitted QC: 2024-10-31
• Last Update Submitted: 2024-10-31
• Study First Posted: 2024-11-01
• Last Update Posted: 2024-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 239607

Inclusion Criteria

• Individuals diagnosed with allergic rhinitis or asthma.
• Availability of genetic data in the UK Biobank or Finnish biobank.

Exclusion Criteria

• Individuals without genetic data.
• Participants with incomplete phenotype or genotype data.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Causal Effect of Asthma on Allergic Rhinitis Risk	Oct 24 2024	Estimate the causal effect of asthma on allergic rhinitis risk using bidirectional Mendelian randomization. This measure includes odds ratios (OR) derived from inverse-variance weighting (IVW), Mendelian randomization-Egger (MR-Egger), and weighted median methods.
Causal Effect of Allergic Rhinitis on Asthma Risk	Oct 24 2024	Estimate the causal effect of allergic rhinitis on asthma risk using bidirectional Mendelian randomization. This measure includes odds ratios (OR) derived from inverse-variance weighting (IVW), Mendelian randomization-Egger (MR-Egger), and weighted median methods.

Secondary Outcome Measures

Name	Time	Method
Sensitivity Analysis Using Leave-One-Out Test	Oct 24 2024	Conduct a leave-one-out test to evaluate the robustness of the causal estimates between allergic rhinitis and asthma by sequentially removing each single nucleotide polymorphism (SNP).
Sensitivity Analysis Using MR-Egger Intercept Test	Oct 24 2024	Perform sensitivity analysis using the Mendelian randomization-Egger (MR-Egger) intercept test to assess horizontal pleiotropy in the causal estimates between allergic rhinitis and asthma.
Sensitivity Analysis Using MR-PRESSO	Oct 24 2024	Use the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test to detect and correct for outliers, assessing heterogeneity in the causal estimates between allergic rhinitis and asthma.

Trial Locations

Locations (1)

Guangzhou Institute of Respiratory Diseases, the First Affiliated Hospital of Guangzhou Medical University; 🇨🇳 Guangzhou, Guangdong, China