Comparison of Base Excess in Arterial Blood Gases Between Patients With Severe Preeclampsia and Normotensive Pregnant Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Hypertensive crisis
研究概览
简要总结
The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals. Researchers will measure these values using an arterial blood gas test before delivery or surgery.
This is a prospective cohort study. The researchers will analyze various blood gas parameters, including pH, lactate, and BE, and then correlate the BE values with clinical variables and negative maternal outcomes.
The expected outcome is that a abnormal BE values will be linked to a greater severity of preeclampsia. If this association is confirmed, BE could serve as an additional marker for predicting the severity of the condition and may lay the groundwork for future research on diagnostic and therapeutic standards based on blood gas analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Gestational age: 24-40 weeks
- •Cases: Diagnosis of severe preeclampsia
- •Control: Normal blood pressure
排除标准
- •Metabolic conditions that could hinder the results (diabetic ketoacidosis, sepsis, renal failure).
- •Clinical conditions that could hinder the results (diarrhea, vomit)
- •Recent use of bicarbonate
研究组 & 干预措施
Severe preeclampsia
Pregnant subjects with severe preeclampsia
干预措施: Arterial Blood gases (Diagnostic Test)
Normotensive
Pregnant subjects with normal blood pressure
干预措施: Arterial Blood gases (Diagnostic Test)
结局指标
主要结局
Hypertensive crisis
时间窗: From admission to day three (3) after delivery
Elevation of the blood pressure above 160 (systolic) and 110 (diastolic).
Value of excess base
时间窗: Immediately before delivery
Total measure of excess base measured by gasometry in an arterial blood sample
次要结局
- Lactate(Immediately before delivery)
- Bicarbonate(Immediately before delivery)
研究者
Osvaldo A. Reyes T.
Head of Research Department
Saint Thomas Hospital, Panama