Circulating Biomarkers and Ventricular Tachyarrhythmia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 220
- 试验地点
- 1
- 主要终点
- to evaluate a large population of heart failure patients with regard to circulating biomarkers and rates of subsequent ventricular arrhythmias.
研究概览
简要总结
The purpose of this study is to determine whether levels of inflammatory markers in circulating blood can correlate with risk for dangerous heart rhythms. Patients with systolic heart failure, which has been shown to increase risk for dangerous heart rhythms, will be enrolled. All subjects will have an implantable cardioverter-defibrillator (ICD) in place, which allows regular evaluation of heart rhythm.
详细描述
If you agree to be in this study, you will be asked to the following things:
- you will come into the EP device clinic every three months for one year to have your device interrogated and will complete an EKG
- you will have labs drawn to measure levels of certain markers of inflammation in the body. This information will be used to identify new ways to test for risk of abnormal heart rhythms and other heart disease
- you will review your medications with the study coordinator and along with any recent illnesses or hospitalizations
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •left ventricular ejection fraction [LVEF] <=35%
- •ICD implant
排除标准
- •Recent myocardial infarction (12 weeks)
- •Recent revascularization (12 weeks)
- •Recent hospitalization for any cause (6 weeks)
- •History of rheumatologic disease
结局指标
主要结局
to evaluate a large population of heart failure patients with regard to circulating biomarkers and rates of subsequent ventricular arrhythmias.
时间窗: 1 year
次要结局
未报告次要终点
研究者
Dr. Daniel P Morin, MD MPH FHRS
Cardiac Electrophysiologist, Director of Cardiovascular Research
Ochsner Health System