Doxycycline after sinus surgery

Phase 4

Recruiting

• Conditions: Chronic rhinosinusitis; Surgery - Other surgery; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12621000674831
• Lead Sponsor: Dr. Andrew James Wood

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-03
• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Patient undergoing Bilateral Comprehensive Endoscopic Sinus Surgery for the treatment of chronic rhinosinusitis as defined by the European Position Statement, 2020

Exclusion Criteria

Prior sinus surgery
Predisposing condition (e.g. Aspirin exacerbated respiratory disease, Granulomatosis with Polyangitis, Cystic fibrosis)
Antibiotic usage in the 4 weeks prior to recruitment.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
22-item Sino Nasal Outcome Tool (SNOT-22) score[ 3 months post-operative]

Secondary Outcome Measures

Name	Time	Method
22-item Sino Nasal Outcome Tool (SNOT-22) score[ 2 weeks and 12 months post-operative];Modified Lund Mckay Postoperative Endoscopy Score (MLMES) Reference: Snidvongs et al. Rhinology. 2013[ 3 months post-operative];Change in sinus mucus microbial ecology assessing the resident microflora of sinus mucus using PCR to amplify microbial DNA[ Intra-operative and at 2 weeks and 3 months post-operative];Patient reported adverse events including but not limited to rash, diarrhoea, vomiting, abdominal pain via documentation of verbal feedback[ Entire time course over which study drug and placebo are administered];Cytokine levels in sinus mucus via swab collection and assay[ Intra-operative and at 2 weeks and 3 months post-operative]