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Clinical Trials/NCT05902858
NCT05902858
Enrolling By Invitation
Not Applicable

Efferct of Standard Laryngoscopy Versus Video-laryngoscop on First-attempt Success in Difficult Airways Undergoing ProVu TM Video Stylet Guided Intubationa (PROVU)

Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria1 site in 1 country114 target enrollmentJanuary 18, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Difficult Intubation
Sponsor
Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Enrollment
114
Locations
1
Primary Endpoint
Success rate on first intubation attemps
Status
Enrolling By Invitation
Last Updated
2 years ago

Overview

Brief Summary

The aim of this open-label, randomized, 3-parallel arm trial is to compare success of intubation rate at first try between three groups that will be intubated:

  1. Conventional intubation with hyperangulated videolaryngoscope (control group),
  2. Intubation ProVu TM video stylet combined with hyperangulated videolaryngoscope,
  3. Intubation ProVu TM video stylet combined with standard Macintosh laryngoscope.

Detailed Description

Critical anesthetic incidents in the operating room are often related to airway management. Difficult airway management is defined as the clinical situation in which an anesthesiologist with conventional training has difficulty with upper airway face mask ventilation, difficulty with tracheal intubation, or both. Airway management has undergone a major transformation since the development of hyper-angle videolaryngoscopy (VL). Recently, the ProVuTM video stylet (Flexicare Medical Ltd, Mountain Ash, UK), which combines visualization technology with a tube guidance system, has been proposed as a new device for endotracheal intubation in participants with difficult airway management. The investigators hypothesized that the ProVuTM video stylet combined with videolaryngoscopy or standard laryngoscopy may improve the success rate of intubation on the first attempt compared with using a videolaryngoscope alone in patientes with predicted difficult intubation. In fact, using ProVuTM the position of the video stylet tip can be adjusted continuously during the tracheal intubation maneuver.

Registry
clinicaltrials.gov
Start Date
January 18, 2023
End Date
June 2023
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • patients undergoing elective surgery requiring oral tracheal intubation;
  • ≥18 years of age;
  • simplified Arné score ≥11;
  • Written informed consent will be obtained from every participant.

Exclusion Criteria

  • ≤18 years of age
  • interincisor distance at maximal mouth opening ≤2 cm;
  • planned awake fiberoptic intubation because patients are patients considered to be high-risk for difficult intubation or difficult mask ventilation (e.g. with neck tumours, complete cervical arthrodesis; neck circumference \>50 cm);
  • patients at risk of gastric aspiration
  • planned nasal intubation.

Outcomes

Primary Outcomes

Success rate on first intubation attemps

Time Frame: During the procedure

The first-attempt intubation success is defined as tracheal tube placement with a single maneuver after insertion of the tube in the mouth. Reinsertion of the tube in the mouth counts as an additional attempt.

Secondary Outcomes

  • Time of intubation(During the procedure)
  • Number of intubation attempts(During the procedure)
  • Complications(During the procedure)
  • Use of "jaw trust" or "BURP"(During the procedure)
  • Need of another anesthesiologist intervention(During the procedure)
  • Time of laryngoscopy(During the procedure)
  • Needs to change the path of the intubation strategy(During the procedure)
  • Learning curve analysis of time of procedure(Through study completion, an average of 1 year)
  • Learning curve analysis of intubation rate success(Through study completion, an average of 1 year)

Study Sites (1)

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