Comparing Different Regional Blocks for Analgesia After Off-pump Cardiac Surgery

Not Applicable

Active, not recruiting

• Conditions: Analgesia
• Interventions: Other: Superficial Parasternal Intercostal Plane Block combined with Rectus Sheath Block; Other: Erector Spinae Plane Block

• Registration Number: NCT05763810
• Lead Sponsor: Abd-Elazeem Abd-Elhameed Elbakry

Brief Summary

This study aims to compare the analgesic effects of erector spinae plane block versus Superficial Parasternal Intercostal Plane Block block along with rectus sheath block after off-pump cardiac surgery

Detailed Description

General anaesthesia will be used for all patients. induction by midazolam 0.05-0.1 mg/kg, fentanyl 2-5 µ/kg, propofol 1-2 mg/kg, and atracurium 0.5 mg/kg for intubation. Maintenance by sevoflurane in oxygen-air mixture. regional blocks will be used after the induction of anaesthesia. Intraoperative analgesia will be maintained by fentanyl infusion 1-2 µ/kg/h while morphine sulphate 2.5-5mg will be used as rescue analgesia when pain score\>4 beside acetaminophen 1000 mg /6 hours

Study Timeline

• Study First Submitted: 2023-02-28
• Study First Submitted QC: 2023-02-28
• Study First Posted: 2023-03-10
• Study Start: 2023-03-15
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-05
• Last Update Posted: 2025-05-06
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• American Society of anaesthesiologists physical status classification II-III
• Elective off-pump cardiac surgery

Exclusion Criteria

• Cognitive impairment
• Allergy to local anaesthetics
• Renal and/or hepatic dysfunction
• Ejection fraction< 45%

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Superficial Parasternal Intercostal Plane Block and Rectus Sheath Block group	Superficial Parasternal Intercostal Plane Block combined with Rectus Sheath Block	Superficial Parasternal Intercostal Plane Block and Rectus Sheath Block
Erector Spinae Plane Block group	Erector Spinae Plane Block	Erector Spinae Plane Block

Primary Outcome Measures

Name	Time	Method
Total opioid consumption	Perioperative.	µg and mg

Secondary Outcome Measures

Name	Time	Method
Postoperative vomiting	Perioperative	number (%)
Duration of hospital stay	Postoperative up to 4 weeks	days
Extubation time	Perioperative	minutes
Pain intensity at rest and exercise	Perioperative.	Visual analogue score: a score from 0 to 10(0= no pain and 10 the worst imaginable pain)
Duration of post anaesthesia care unit stay	Perioperative	minutes
Postoperative nausea	Perioperative	number (%)

Trial Locations

Locations (1)

Faculty of Medicine; 🇪🇬 Cairo, Shebin Elkom, Egypt