Assessment of Chronic Kidney Disease in Non Alcoholic Fatty Liver Disease(NAFLD) Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- prevalence of chronic kidney disease in nafld patient
研究概览
简要总结
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. This disease reportedly affects up to 30% of the general population in Western countries, especially in patients with metabolic syndrome, obesity, and type II diabetes. NAFLD is considered to be an independent risk factor for cardiovascular disease and there is accumulating evidence to support a causative role in the development of chronic kidney disease (CKD). So, we aim first to assess the prevalence of chronic kidney disease in NAFLD patients, secondly to detect the association between hepatic fibrosis and CKD in NAFLD patients
详细描述
This study will be conducted on 100 patients 70 patients diagnosed to has NAFLD by ultrasonography presented to the outpatient clinic of Sohag University Hospital, and A control group of 30 healthy volunteers who looks normal on ultrasonography from February 2021 to July 2021.
Methods:
All included patients will be subjected to:
- Detailed history, complete general and systemic examination .
- BMI will be calculated as follow
- Abdominal Ultrasonography.
- Laboratory investigations:
Fasting and post-prandial blood sugar Serum lipogram. Liver function tests. Serum creatinine, Albumin -creatinine Ratio. 5. Calculation of estimated Glomerular Filtration Rate eGFR. 6. Liver stiffness measurements to detect degree of fibrosis and measurement of the degree of steatosis using (Fibroscan)
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients diagnosed to has NAFLD by ultrasonography presented to the outpatient clinic of Sohag University Hospital
排除标准
- •Diabetic patients.
- •Hypertensive patients.
- •Other causes of chronic liver disease rather than NAFLD.
结局指标
主要结局
prevalence of chronic kidney disease in nafld patient
时间窗: February 2021 to July 2021
correlation of chronic kidney disease and degree of hepatic fibrosis in nafld patient
时间窗: February 2021 to July 2021
次要结局
未报告次要终点
研究者
Mona Mohammed Abdelrhman
Principal investigator
Sohag University