Effect of early mobilisation combined with additional protein on muscle mass in critically ill patients
Completed
- Conditions
- Alle patienten opgenomen op de ICU voor tenminste 72 uurCritical illnessmuscle weakness
- Registration Number
- NL-OMON46556
- Lead Sponsor
- Medisch Spectrum Twente
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
- Expected to stay on the ICU for at least 72 hours.
- Complete enteral nutrition. Or enteral nutrition in combination with parenteral or oral nutrition.
Exclusion Criteria
- Complete parenteral feeding
- Chronic renal failure or hepatic encephalopathy
- Acute kidney injury without CVVH or IHD
- Poor prognosis
- Progressive neuro-muscular disease or neurotrauma as reason for ICU admission
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the percent change in muscle thickness of the<br /><br>mid-upper arm, forearm and thigh measured by ultrasonography, from baseline to<br /><br>ICU admission.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secundary study parameters are:<br /><br>* Muscle quality of the rectus femoris and vastus intermedius muscles<br /><br>separately (echogenicity) measured by ultrasonography.<br /><br>* Muscle force measured by MRC sum score and handgrip force<br /><br>* Functional status (DEMMI)<br /><br>* Nutritional state and hydration status with the bivameter.<br /><br>* Quality of life (EQ-5D)</p><br>