Biomarkers for Pain in Spinal Cord Injury (SCI) Patients
- Conditions
- Traumatic Spinal Cord InjuryNeuropathic Pain
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 120
A. Chronic Patients<br><br>Inclusion:<br><br> 1. Two or more years post traumatic SCI with deficit<br><br>Exclusion:<br><br> 1. < 18 years of age<br><br> 2. Evidence of brain injury on computed tomography (CT) (SCI patients need to be able<br> to comply with completing the pain survey)<br><br> 3. Other medical condition that accounts for chronic pain (i.e. diabetic neuropathy,<br> renal insufficiency, multiple sclerosis, HIV associated neuropathy, alcohol-related<br> neuropathy)<br><br> 4. Temperature > 100.5°C<br><br> 5. History of infection within the last 30 days (i.e. UTI, URI, pressure sore)<br><br> 6. History of Pulmonary Embolus (PE) or deep vein thrombosis (DVT)<br><br> 7. Inability to obtain informed consent<br><br> 8. Psychiatric problems (patients need to be able to complete the pain survey)<br><br> 9. Diagnosis or treatment of cancer in the last 5 years<br><br>B. Longitudinal, Prospective Cohort Patients:<br><br>Inclusion:<br><br> 1. Initial traumatic SCI with deficit<br><br>Exclusion:<br><br>Same as listed above C. Healthy Volunteers Healthy volunteers include gender, age and<br>race matched volunteers able to provide informed consent who have,<br><br> 1. No significant medical history (pain free)<br><br> 2. No recent infections<br><br> 3. Take no medications<br><br> 4. Fever free<br><br> 5. Greater than 18 years old
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To identify candidate biomarkers for pain in the chronic SCI samples.
- Secondary Outcome Measures
Name Time Method To identify the temporal relationship of the development of pain and the manifestation of the biomarkers identified