Determination of central pain modulation biomarkers to characterize and profile cancer patients with refractory pai

Not Applicable

• Conditions: Assessment of cancer pain in patients with breast, pancreatic, lung or colon cancer.; Signs and Symptoms

• Registration Number: ISRCTN35887998
• Lead Sponsor: niversity of Santiago de Compostela

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-05-30
• Last Update Posted: 8 January 2024
• Study Completion: 2026-05-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 750

Inclusion Criteria

Cancer patients with pain:
1. Adult subjects = 18 years old
2. Able to provide informed consent to participate in the study
3. Able to self-report pain
4. To have a diagnosis of cancer affecting the lung, breast, pancreas or colon (with metastases or not)
5. The life expectancy of at least six months
6. Cancer pain persisting despite best-tolerated pharmacological treatment
7. Pain rated =5 on a 0-10 Numeric Rating Scales (NRS) persisting for over 1 month prior to enrolment
8. Ability to use the internet and WhatsApp or have a person (relative, caregiver) to help them

Cancer patients with no pain:
1. Adult subjects = 18 years old
2. Able to provide informed consent to participate in the study
3. Able to self-report pain
4. To have a diagnosis of cancer affecting the lung, breast, pancreas or colon (with metastases or not)
5. The life expectancy of at least six months
6. No chronic pain after cancer disease or treatment
7. Ability to use the internet and WhatsApp or have a person (relative, caregiver) to help them

Exclusion Criteria

Cancer patients with pain:
1. Pregnant women or women of fertile age that did not have efficacious contraception during the whole period of the study
2. Neurological or psychiatric diseases (except anxiety or depression)
3. Unstable medical conditions (e.g., uncontrolled diabetes, uncompensated cardiac issues, heart failure or chronic obstructive pulmonary disease)
4. History of neurosurgery, traumatic brain injury with loss of consciousness, and/or cortical lesions
5. Present risk factors for receiving tES (e.g., history of epilepsy, metal devices in the brain, etc.)
6. History of non-malignant chronic pain

Cancer patients with no pain:
1. Pregnant women or women of fertile age that did not have efficacious contraception during the entire period of the study.
2. Neurological or psychiatric diseases (except anxiety or depression).
3. Unstable medical conditions (e.g., uncontrolled diabetes, uncompensated cardiac issues, heart failure or chronic obstructive pulmonary disease).
4. History of neurosurgery, traumatic brain injury with loss of consciousness, and/or cortical lesions.
5. History of non-malignant chronic pain.

Study & Design

• Study Type: Observational
• Study Design: Not specified