Development, validation and clinical use of the dynamic pruritus score (DPS)

• Conditions: L29.9; Pruritus, unspecified

• Registration Number: DRKS00005970
• Lead Sponsor: niversitätsklinikum Münster

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2013-10-11
• Study Start: 2014-04-15
• Results First Posted: 2016-07-25
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 157

Inclusion Criteria

Age >18, male and female, out- and in-patients with atopic dermatitis, urticaria, prurigo nodularis and chronic pruritus.
The patients received a topical therapy (between V1 and V2) during the study for 2 weeks.

Exclusion Criteria

Age below 18 years, pregnancy, breastfeeding, active psychosomatic and psychiatric disorders, known active malignant underlying diseases, previous studies within the last 4 weeks, drug use, drug abuse, topical application of tacrolimus, pimecrolimus, polidocanol, menthol, cannabinoid agonists or capsaicin within the last 2 weeks prior to the study, systemic administration of steroids, cyclosporine A and other immunosuppressive agents, naltrexone, UV therapy within the last two weeks before the study start, systemic administration of antihistamines, topical steroids within one week prior to the study, acute exacerbation or cutaneous infections in atopic dermatitis

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Calculation of correlation coefficients of the PruDPS (dynamic pruritus score) with VAS.<br>The calculation is based on the indication of a change in pruritus from day 1 to day 14.

Secondary Outcome Measures

Name	Time	Method
Correlation of PruDPS with other intensity scales (VAS today, VAS average last four weeks, VAS worst last four weeks, NRS today, VRS today) based on the Neuroderm questionnaire, survey the quality of life by DLQI and HADS, PBI-P, histamine intrakutan testing, neurometer stimulation, corneometry, EQ-5D. <br><br>The collection of data is done on day 1 (V1) and day 15 (V2). <br>The DPS is assessed at the 2nd visit on day 15 by means of the scale-smiley-bar and the retro-VAS <br>