The use of a low carbohydrate, high fat diet for the treatment of epilepsy in adults

Not Applicable

• Conditions: Medically refractory epilespy; Neurological - Epilepsy

• Registration Number: ACTRN12614001027606
• Lead Sponsor: Royal Melbourne Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-09-24
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Aged 18-75 years
Diagnosed epilepsy, whether taking AEDs or not, experiencing two or more seizures in four weeks of one or more of the following types of seizures:
complex partial seizures (focal dyscognitive seizures)
secondary generalised tonic clonic seizures
simple partial seizures with motor features
primary generalised tonic clonic seizures
tonic seizures
atonic seizures
No changes in AEDs or vagus nerve stimulation (VNS) settings for one month prior to enrolment

Exclusion Criteria

Under 18 years of age
Body mass index < 18.5kg/m2
Patients with cluster seizures or who are unable to count or describe their seizures
Patients experiencing myoclonic or absence seizures only
Patients experiencing non-epileptic seizures
Diabetes Mellitus
Fatty acid or amino acid oxidation disorders
Pre-existing renal and/or liver failure
Currently on the ketogenic diet
Prior history of eating disorders
Females who are pregnant or breastfeeding

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequency of seizures per 28 days as recorded in the seizure diary[After 3 months on the modified atkins diet]