Exploring the Power of Theacrine: Assessing the Impact of High Theacrine Doses on Hemodynamic Measures, Cognitive Measures, and Physiological Stress
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Change in systolic blood and diastolic blood pressure post consumption of theacrine
研究概览
简要总结
This project measured physiological and cognitive variables to determine the effectiveness of Theacrine (TCR) as a stimulant at doses greater than those previously tested. The study will be the first TCR study to use doses relative to body weight and will investigate impacts on regular caffeine consumers. A secondary aim of the study is to determine the impact of acute TCR supplementation on salivary cortisol and sAA, two physiological measures of stress and sympathetic nervous system activation. The findings of the study will provide new insight into the effects of higher TCR dosages, contributing to the analysis of TCR as a caffeine alternative for individuals with hypertension, tachycardia, or healthy caffeine consumers wanting to avoid a stimulant with adverse or habitual effects
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- habitual caffeine consumer (≥2 days/week)
排除标准
- •existing heart disease or conditions (cardiovascular and/or heart disease, stroke, diabetes hypertension, tachycardia)
- •allergy to caffeine or Theacrine
- •caffeine sensitivity (negative symptoms such as jitters after consuming low doses)
- •on heart or blood pressure medication
研究组 & 干预措施
Placebo
6 mg/kg Maltodextrin Placebo
干预措施: Maltodextrin (Placebo) (Dietary Supplement)
Low dose
3mg/kg Theacrine
干预措施: Low dose theacrine (Dietary Supplement)
Medium dose
6mg/kg Theacrine
干预措施: Medium dose theacrine (Dietary Supplement)
High dose
9mg/kg Theacrine
干预措施: High dose theacrine (Dietary Supplement)
结局指标
主要结局
Change in systolic blood and diastolic blood pressure post consumption of theacrine
时间窗: Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine
mmHg change in blood pressure measures
Change in heart rate post consumption of theacrine
时间窗: Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine
beats per minute change in heart rate measure
Changes in executive function as a measure of cognitive performance using the Trail Making Test
时间窗: Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine
Time to completion of the Trail Making Test as a measure of executive function
Changes in attention as a measure of cognitive performance using the Flanker Inhibitory Control and Attention task
时间窗: Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine
Accuracy of congruent and incongruent trials as measures of attention
Changes in focus as a measure of cognitive performance using the Flanker Inhibitory Control and Attention task
时间窗: Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine
Reaction time were recorded as measures of focus
次要结局
- Change in salivary cortisol and alpha-amylase post consumption of theacrine(Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine)
研究者
Titch Madzima
Associate Professor
Elon University