2024-515400-40-00招募中4 期
IMpact of Phenylephrine vs. norAdrenaline on systemic hemodynamics and Cerebral Tissue circulation and oxygenation in anesthetized brain tumor patients (IMPACT)
Region Midtjylland1 个研究点 分布在 1 个国家目标入组 32 人开始时间: 2024年7月4日最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- The primary endpoint is the between-group difference in ΔCBF (Δ= posttreatment value-pretreatment value).
研究概览
简要总结
In the attempt to improve brain outcomes, we initiate this interdisciplinary and international collaborative project to understand the impact of two commonly used vasopressor agents (phenylephrine vs. noradrenaline) on cerebral circulation and oxygenation in patients undergoing brain tumor resection. We also aim to understand the impact of vasopressor-induced changes in systemic hemodynamics on regional perfusion in organs including the brain, heart and muscle.
入排标准
- 年龄范围
- 18 years 至 65+ years（65+ Years, 18-64 Years）
- 接受健康志愿者
- 否
入选标准
- •Subjects aged 18-75 yr. scheduled for elective craniotomy for supratentorial tumors with a minimum size of 3 cm (measured as the largest diameter in any plane) are included
排除标准
- •Exclusion criteria are history of allergy or intolerance to one of the study medications, an American Society of Anesthesiologists (ASA) physical status IV to VI, pregnancy (positive pregnancy urine test) or breastfeeding and inability to give written informed consent
结局指标
主要结局
The primary endpoint is the between-group difference in ΔCBF (Δ= posttreatment value-pretreatment value).
The primary endpoint is the between-group difference in ΔCBF (Δ= posttreatment value-pretreatment value).
次要结局
未报告次要终点
研究者
Mads Rasmussen
Scientific
Region Midtjylland
研究点 (1)
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