Comparison of Neuromuscular and Functional Adaptations to 10% and 30% Velocity-Loss Threshold Resistance Training in Persons With Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in neuromuscular performance as measured by 1-repetition maximum (1RM)
研究概览
简要总结
This study will compare the effects of velocity-loss resistance training at 10% and 30% velocity loss thresholds on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Parkinson's Disease Hoehn & Yahr Stages 1-3
- •Able to walk 50 meters unassisted
- •Able to understand and communicate in English
排除标准
- •Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
- •Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
- •Unresolved injury or surgery to the upper or lower limbs that prevents weight training.
研究组 & 干预措施
10% Velocity-Loss Threshold Resistance Training
Participants will receive velocity-based resistance training at 10% velocity-loss threshold, twice per week for at least 24 sessions for up to 12 weeks.
干预措施: 10% Velocity-Loss Threshold Resistance Training (Behavioral)
30% Velocity-Loss Threshold Resistance Training
Participants will receive velocity-based resistance training at 30% velocity-loss threshold, twice per week for at least 24 sessions for up to 12 weeks.
干预措施: 30% Velocity-Loss Threshold Resistance Training (Behavioral)
结局指标
主要结局
Change in neuromuscular performance as measured by 1-repetition maximum (1RM)
时间窗: Baseline, 12 weeks
Maximal load that can be lifted in one repetition (1RM) will be assessed in both leg press and chest press exercises. The loads on the testing equipment will be increased across 5 to 7 testing repetitions. The persons 1RM will be the highest load the person can move through the range of motion of the exercise. There are no minimum or maximum scores for this test. The higher the 1RM the stronger the person is. The unit of measurement is kilograms.
Change in neuromuscular performance as measured by Watts
时间窗: Baseline, 12 weeks
This test measures the power a person can produce at maximal speed using loads of 20%, 40%, 60%, 80%, and 90% of 1RM for the chest press and leg press. Power shows how fast a person can do work. There are no minimum or maximum possible values. Higher values indicate better neuromuscular performance. Unit of measure is Watts.
次要结局
- Change in the Speed of the Ten-Meter Walk Test.(Baseline, 12 weeks)
- Change in Time for the Five Times Sit-to-Stand Test.(Baseline, 12 weeks)
- Change in the time required to complete the timed Up-and-Go Test.(Baseline, 12 weeks)
- Change in Distance of the Seated Medicine Ball Throw.(Baseline, 12 weeks)
- Change in Muscle Thickness using Ultrasound.(Baseline, 12 weeks)
- Change in Muscle Quality using Ultrasound.(Baseline, 12 weeks)
研究者
Joseph Signorile
Professor
University of Miami