Prediction Score for the International Normalized Ratio in Patient with Paracetamol Overdose Ingestio
- Conditions
- Patient with Paracetamol Overdose Ingestion,INR levelInternational Normalized RatioINRParacetamol overdoseParacetamol toxicityAcetaminophen overdoseAcetaminophen toxicity
- Registration Number
- TCTR20211025005
- Lead Sponsor
- Emergency Medicine Department, Faculty of Medicine, Chiang Mai University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 38
Inclusion Criteria
1)Patients who had ingested acetaminophen more than 150 mg/Kg or 7.5 grams within a single 4-hour period (Acute overdose)
2)Patients who had measured prothrombin time (PT) and INR
Exclusion Criteria
1.Coingested substances reported to interfere CYP2E1 eg. SSRI
2.On CYP inducer drug eg.Isoniazid, Rifampin, Anti-convulsant
3.On anticoagulant eg.warfarin
4.Documented of liver disease
5.Advanced cancer
6.Present evident of acetaminophen induced hepatotoxicity while taken blood for INR level eg. AST or ALT more than 1000 unit/liter
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Predicted INR level First INR lab result at the beginning of study INR level
- Secondary Outcome Measures
Name Time Method /A N/A N/A