Specialized Pro-resolving Mediators (SPM) as Biomarkers of Periodontal Inflammation

Not Applicable

Recruiting

• Conditions: Periodontitis; Inflammation
• Interventions: Procedure: Non surgical periodontal therapy

• Registration Number: NCT05706675
• Lead Sponsor: University of Sharjah

Brief Summary

Periodontal diseases are a public health burden in all countries. Hence, Periodontitis is the sixth-most prevalent disease in the world, the most common bone diseases in human and the primary cause for tooth loss in adults leading to significant economic and medical consequences. All disease biomarkers could help to stratify the general population with those at high risk of periodontitis and to enroll them in a rigorous prevention program. Advanced periodontitis has been shown to reduce the quality of life of patients and developing novel biological monitoring protocols will reduce the prevalence of advanced forms of the disease.

There are alot of research explaining the different types of inflammatory mediators that could be found in periodontitis patients. But there are a few research have been talking about lipoxin A4 as an inflammatory biomarker that could detect the effect of non surgical periodontal therapy effect on the periodontal health.

And the aim of the study is to assess the effect of this non surgical periodontal therapy on the periodontal health by assessing the concentration of this biomarker.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-01
• Status Verified: 2023-01
• Study First Submitted: 2023-01-21
• Study First Submitted QC: 2023-01-21
• Last Update Submitted: 2023-01-21
• Study First Posted: 2023-01-31
• Last Update Posted: 2023-01-31
• Primary Completion: 2023-10
• Study Completion: 2024-06

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Control group : Patients diagnosed as periodontally healthy

• Test group:

  • Patients diagnosed with generalized periodontitis (Stage 3/4, Grade a,b or c).
  • Having at least 15 remaining teeth.
  • Mentally able to understand the communication and to express an informed consent

Exclusion Criteria

• Systemic diseases with known effect on periodontal health
• Antibiotics/Anti-inflammatory drugs taken in the last month
• Women with suspected/known pregnancy, or taking any hormone-based treatment
• Patients suffering from Xerostomia.
• Patients smoking more than 20 cig/day.
• Previous periodontal therapy in the last 3-6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experimental	Non surgical periodontal therapy	Periodontitis patients that will be treatyed with Non surgical Periodontal Therapy

Primary Outcome Measures

Name	Time	Method
Lipoxin A4	2 months	Gingival crevicular fluid concentration

Trial Locations

Locations (1)

University Dental Hospital Sharjah; 🇦🇪 Sharjah, United Arab Emirates