The Effect of Sugammadex Given Based on Ideal, Actual or Adjusted Body Weights on Reversal of Neuromuscular Blockade in Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Reversal Time
研究概览
简要总结
The aim of this study is compare the reversal of rocuronium induced neuromuscular blockade in morbidly obese patients using three doses of sugammadex; based on ideal body weight, adjusted body weight, and actual body weight.
详细描述
The aim of this study is compare the reversal of rocuronium induced neuromuscular blockade in morbidly obese patients using three doses of sugammadex; based on ideal body weight, adjusted body weight, and actual body weight. Reversal Time: time from administration of Sugammadex to train of four (TOF) ratio ≥ 0.9 will be used as primary outcome.
Time need for extubation (time from administration of sugammadex to extubation), and duration of stay in post anesthesia care unit (PACU), will be used as secondary outcome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients older than 18 years and under 45 years,
- •body mass index ≥ 40 kg/m2, with indication of bariatric surgery
排除标准
- •Patients with comorbid including: neuromuscular disease, renal impairment, and patients with difficult airway were excluded from this study.
研究组 & 干预措施
Group A
Sugammadex given in a dose of 2mg/kg based on ideal body weight
干预措施: Sugammadex (Drug)
Group B
Sugammadex given in a dose of 2mg/kg based on adjusted body weight
干预措施: Sugammadex (Drug)
Group C
Sugammadex given in a dose of 2mg/kg based on actual body weight
干预措施: Sugammadex (Drug)
结局指标
主要结局
Reversal Time
时间窗: 5 minutes after sugammadex administration
Reversal Time: time from administration of Sugammadex to train of four (TOF) ratio ≥ 0.9 will be used as primary outcome.
次要结局
- duration of stay in PACU(60 minutes after admission to the PACU)
- Time need for Extubation(10 minutes after sugammadex administration)
研究者
Walid Nofal
Lecturer of Anesthesiology
Ain Shams University