Pilot study to review alternative assessments of adequacy of dialysis in patients with kidney failure
Not Applicable
Completed
- Conditions
- Renal and cardiacUrological and Genital Diseases
- Registration Number
- ISRCTN70556765
- Lead Sponsor
- Royal Free Hospital (UK)
- Brief Summary
2015 results in https://pubmed.ncbi.nlm.nih.gov/25761438/ (added 17/12/2020)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
1. Treated for chronic kidney failure
2. Ability to provide informed consent
Exclusion Criteria
1. Unable to provide informed consent
2. Aged below 18 years
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> To determine the practicability of measuring skin autofluorescence, endotoxin and modified albumin in the study population and whether these factors correlate with conventional markers of dialysis adequacy.<br><br> Blood samples will be taken at entry into the study and then at 12 months to determine concentrations of endotoxin and modified albumin. Similarly blood pressure, ECG and skin autofluorescence will be measured at study entry and then at 12 months. Measurements of arterial size will be made once at study entry.<br>
- Secondary Outcome Measures
Name Time Method To determine whether skin autofluorescence, endotoxin and modified albumin correlate with cardiovascular risk factors