Evaluating the effects of vitamin B1, B6, B12 and folic acid supplementation in women with episodic migraine
- Conditions
- migraine headache.Migraine
- Registration Number
- IRCT20190921044828N1
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 100
Body mass index 18.5-30
Aged 18-50 years old
Migraine diagnosis according to The Classification Committee of the International Headache Society (IHS) 3rd edition (beta version)
Episodic migraine with 3 attacks or more per month
Suffering from migraine for at least 6 months prior to study
Unwillingness to participate in the study
Taking vitamin B group supplements in 3 months prior to study
Pregnancy and lactation
Taking anti-psychotic drugs
Suffering from gastrointestinal disorders (malabsorption,IBD,...),diabetes, liver disorders(Cirrhosis, Hepatitis), kidney disorders(Kidney Failure), congestive heart failure, hypertension,cancer
Smoking
Changes in dosage and type of migrane prophylactic drugs during intervention
Not taking more than 10% of supplements
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Migraine attack frequency per month. Timepoint: baseline-end of study. Method of measurement: headache diary.;Attack severity. Timepoint: baseline-end of study. Method of measurement: headache diary-visual analogue scale.;Headache attack duration (min per month). Timepoint: baseline-end of study. Method of measurement: headache diary.
- Secondary Outcome Measures
Name Time Method Serum homocysteine. Timepoint: baseline- end of study. Method of measurement: ELISA KIT.;Serum endothelial nitric oxide synthase. Timepoint: baseline- end of study. Method of measurement: ELISA KIT.;Serum Calcitonin gene-related peptide (CGRP). Timepoint: baseline- end of study. Method of measurement: ELISA KIT.