Branched Chain Aminoacid Supplementation in Patients With Liver Cirrhosis
Phase 4
Completed
- Conditions
- Liver Cirrhosis
- Interventions
- Dietary Supplement: Branched-chain aminoacidsOther: High-fiber high protein diet
- Registration Number
- NCT02023229
- Lead Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
- Brief Summary
Malnutrition is a frequent complication in patients with liver cirrhosis. Most patients have decreased dietary intake due to ascites, hepatic encephalopathy and pro-inflammatory cytokines.
We hypothesized that branched chain aminoacids can improve nutritional status and delay episodes of hepatic encephalopathy
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 68
Inclusion Criteria
Ambulatory patients Patients with confirmed diagnose of liver cirrhosis Patients classified as Child-Pugh A or Child Pugh B
Exclusion Criteria
Acute or chronic renal failure Pregnancy Overt hepatic encephalopathy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Diet plus branched chain aminoacids Branched-chain aminoacids High-fiber high-protein diet Oral supplement : branched chain aminoacids Diet plus branched chain aminoacids High-fiber high protein diet High-fiber high-protein diet Oral supplement : branched chain aminoacids Diet High-fiber high protein diet High-fiber high-protein diet
- Primary Outcome Measures
Name Time Method Nutritional status At time of recruitment Assessed by bioelectrical impedance vector analysis and mid-arm muscle circumference
- Secondary Outcome Measures
Name Time Method Hepatic Encephalopathy At time of recruitment
Trial Locations
- Locations (1)
Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"
🇲🇽Mexico city, Mexico