Azithromycin Versus Doxycycline on Restistin Level in Periodontitis Patients With Type 2 Diabetes

Phase 1

Completed

• Conditions: Periodontal Diseases; Type 2 Diabetes
• Interventions: Drug: Group I; Drug: Group II; Drug: Group III

• Registration Number: NCT06199440
• Lead Sponsor: King Abdulaziz University

Brief Summary

The aim of this study is to evaluate the adjunctive effects of systemic antibiotics used in nonsurgical periodontal treatment (NSPT), compared with NSPT alone, on the periodontal clinical parameters and resistin level in diabetic patients with periodontitis, in order to identify which, one provides an additional effect to non-surgical periodontal therapy

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-01
• Primary Completion: 2023-03-30
• Study Completion: 2023-03-30
• Status Verified: 2023-12
• Study First Submitted: 2023-12-29
• Study First Submitted QC: 2023-12-29
• Last Update Submitted: 2023-12-29
• Study First Posted: 2024-01-10
• Last Update Posted: 2024-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Patients were clinically diagnosed as having at least three site with CAL ≥ 5mm; moderate to advanced chronic periodontitis according to the criteria of American Academy of Periodontology.

• Free from any other systemic conditions that affect the periodontium except for Diabetes mellitus type II.
• No periodontal therapy, systemic antibiotics or non-steroidal anti-inflammatory agents during the preceding 6 months.
• Non-smokers.
• Non-pregnant.

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group I	Group I	Chronic periodontitis patients with diabetes mellitus type II who received scaling and root planning.
Group II	Group II	Received azithromycin dosage is 250 mg/day for 5 days, after an initial dose of 500 mg one hour before NSPT
Group III	Group III	Consisted of 5 type 2 Diabetes Mellitus patients with periodontitis who were received doxycycline 20mg twice/day.

Primary Outcome Measures

Name	Time	Method
Primary Outcome	3 months	Improvements in clinical parameters of periodontitis including Gingival Index, Probing Depth and Clinical Attachment Level

Secondary Outcome Measures

Name	Time	Method
Secondary Outcome	3 months	Improved resistin level

Trial Locations

Locations (1)

King Abdulaziz University; 🇸🇦 Jeddah, Saudi Arabia