Azithromycin Versus Doxycycline on Resistin Level in Periodontitis Patients With Type 2 Diabetes. A Randomized Controlled Clinical Trial
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Primary Outcome
研究概览
简要总结
The aim of this study is to evaluate the adjunctive effects of systemic antibiotics used in nonsurgical periodontal treatment (NSPT), compared with NSPT alone, on the periodontal clinical parameters and resistin level in diabetic patients with periodontitis, in order to identify which, one provides an additional effect to non-surgical periodontal therapy
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 25 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients were clinically diagnosed as having at least three site with CAL ≥ 5mm; moderate to advanced chronic periodontitis according to the criteria of American Academy of Periodontology.
- •Free from any other systemic conditions that affect the periodontium except for Diabetes mellitus type II.
- •No periodontal therapy, systemic antibiotics or non-steroidal anti-inflammatory agents during the preceding 6 months.
- •Non-smokers.
- •Non-pregnant.
排除标准
- 未提供
研究组 & 干预措施
Group I
Chronic periodontitis patients with diabetes mellitus type II who received scaling and root planning.
干预措施: Group I (Drug)
Group II
Received azithromycin dosage is 250 mg/day for 5 days, after an initial dose of 500 mg one hour before NSPT
干预措施: Group II (Drug)
Group III
Consisted of 5 type 2 Diabetes Mellitus patients with periodontitis who were received doxycycline 20mg twice/day.
干预措施: Group III (Drug)
结局指标
主要结局
Primary Outcome
时间窗: 3 months
Improvements in clinical parameters of periodontitis including Gingival Index, Probing Depth and Clinical Attachment Level
次要结局
- Secondary Outcome(3 months)
研究者
Jazia Alblowi
Associate Professor
King Abdulaziz University