Comparison of two types of dose (standard dose versus low dose) intravenous insulin infusion in treatment of children with diabetic ketoacidosis
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Children aged â?¤ 12 years with DKA admitted to Pediatric emergency
- Registration Number
- CTRI/2014/08/004823
- Lead Sponsor
- Pediatric Critical Care Units
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Children aged <= 12 years with DKA admitted to Pediatric emergency. (DKA defined as 1. Hyperglycemia (blood glucose > 200 mg/dL 2. venous pH <7.3 and/or bicarbonate <15 mmol/L
3. Associated glycosuria, ketonuria, and ketonemia)
Exclusion Criteria
1. Children with DKA who already received insulin infusion outside irrespective of duration and dose.
2. Children with a septic shock (requiring >= 60 ml/kg fluid boluses and vasoactive therapy to maintain vitals parameters during initial resuscitation).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the time taken for resolution of DKA in children with DKA receiving low dose insulin infusion (0.05units/kg/hr) as compared to those receiving standard dose (0.1units/kg/hr).Timepoint: Till resolution of DKA
- Secondary Outcome Measures
Name Time Method 1.Rate of fall in RBS till â?¤ 250mg/dl. <br/ ><br>2.Incidence of hypoglycemia and hypokalemia. <br/ ><br>3.Incidence of cerebral edema and / or worsening of cerebral edema.Timepoint: During PICU stay