Heart rate variability and autonomic physiological functions as a predictor of clinical outcome in neurobiological stimulation therapy, in particular electroconvulsive therapy and vagus nerve stimulatio

• Conditions: F32.2; F32.3; Severe depressive episode without psychotic symptoms; Severe depressive episode with psychotic symptoms

• Registration Number: DRKS00016928
• Lead Sponsor: Klinik für Psychiatrie und PsychotherapieUniversitätsklinikum Bonn

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-11
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Women and men who meet the criteria for therapy-resistant depression and who have been given the indication for electroconvulsive therapy and / or vagus nerve stimulation
• Age from 18
• Legally valid consent

Exclusion Criteria

Patients who have a contraindication to electroconvulsive therapy or a contraindication to surgery to implant the Nervus Vagus Stimulator

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
There is no endpoint defined.<br>The aim of the study is to investigate whether it is possible to predict the effect of the neurostimulation therapy and the course of the disease by measuring heart rate variability, noninvasive determination of autonomic nervous system parameters and assessing laboratory parameters in the blood.

Secondary Outcome Measures

Name	Time	Method
There is no secondary outcome defined.