A Randomized Trial Evaluating the Use of Fibrin Tissue Adhesive Following Axillary Node Dissection in Patients With Melanoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 121
- 试验地点
- 1
- 主要终点
- Drain Duration
研究概览
简要总结
Primary Objective:
- To determine whether the use of a fibrin sealant applied to axillary soft tissues following node dissection can result in earlier drain removal.
Secondary Objectives:
- To determine the postoperative morbidity rate using fibrin sealant following axillary node dissection.
- To assess patient-valuation of outcome by performing a cost-benefit analysis using a willingness-to-pay model.
- To determine if serum levels, lymphatic fluids level, or cutaneous expression of vascular endothelial growth factor-D (VEGF-D), vascular endothelial growth factor-C (VEGF-C) or their receptor, vascular endothelial growth factor receptor-3 (VEGFR-3) correlates with nodal tumor burden or development of lymphedema in patients with melanoma.
详细描述
Patients in this study are scheduled to have axillary node dissection as part of their surgery for treatment of their melanoma.
Within 2 weeks before entry into the study, patients will have a complete physical exam and medical history.
These patients will be randomly assigned (as in the toss of a coin) to one of two groups. Patients in one group will receive TISSEEL applied externally to the dissected axillary area. Patients in the other group will receive no fibrin sealant.
For patients who are admitted to the hospital, the surgical site will be monitored by the surgeon for evidence of wound complications in the first 24 hours after surgery. At the time of discharge from the hospital, patients will be instructed in drain care and how to measure the drainage each day until the drain is removed.
The contents of the drain will be collected from patients during the first day after surgery, during the first return follow-up visit to M.D. Anderson Cancer Center, and during drain removal (unless these latter 2 dates are the same).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Part I - Inclusion Criteria, patients that consent to participate.
- •Patients with melanoma who have undergone axillary dissection within the last six months as part of their surgical treatment will be considered for the study.
排除标准
- •Part II - Exclusion Criteria, patients with known hypersensitivity to bovine proteins.
- •Patient has undergone prior radiation therapy to the operative site.
- •Patient is pregnant or lactating.
- •Patient is steroid dependent within prior 6 months.
- •Patient has used aspirin or other anti-platelet drug (excluding Celebrex) within seven days of operation.
- •Patient has pre-existing lymphedema.
- •Patient has other pre-existing medical conditions with evidence of organ dysfunction as determined by principal investigator.
研究组 & 干预措施
Fibrin Sealant
Tisseel applied externally to the dissected axillary area.
干预措施: Fibrin Sealant (Drug)
结局指标
主要结局
Drain Duration
时间窗: from surgery until drain removed, up to 40 days
Number of days drain was in place
次要结局
- Number of Participants With Infection(after surgery until the wound is healed, up to 30 days whichever is longer)