Effect of Plasma Rich in Growth Factors on Semen Quality

Completed

• Conditions: Vascular Endothelial Growth Factor Overexpression
• Interventions: Biological: PRGF in candidates for sperm donors

• Registration Number: NCT02708537
• Lead Sponsor: IVI Bilbao

Brief Summary

The hypothesis is growing semen samples with plasma rich in growth factors (PRGF), because it could improve sperm motility in patients subsidiary TRA, ultimately improving pregnancy rates.

Detailed Description

Platelet growth factors are a group of proteins involved in cellular communication modifying biological responses. Obtaining plasma rich in growth factors is already widespread and simple protocol technique that is being used in various areas of medicine with superb results. Described many of the growth factors present in the PRGF are related to sperm parameters, especially motility The described effects have been studied in mammalian and each growth factor individually. PRGF contains a pool of growth factors and therefore be interesting to analyze their effect on various sperm parameters.

One of those parameters is very important for fertilization sperm motility, since the lack of it will prevent displacement by the cervix to meet the egg in the fallopian tube.

Study Timeline

• Study First Submitted: 2016-03-04
• Study First Submitted QC: 2016-03-09
• Study First Posted: 2016-03-15
• Study Start: 2016-04
• Primary Completion: 2016-07
• Study Completion: 2017-12
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-29
• Last Update Posted: 2022-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• 18-35 years
• more than 5 million sperm per milliliter

Exclusion Criteria

• Not having genetic and infectious diseases
• Do not suffer mental illness
• Have a family study determined that there is no risk of hereditary diseases
• There have fathered more than 6 children in the country

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PRGF in candidates for sperm donors	PRGF in candidates for sperm donors	Prospective study of 58 candidates for sperm donors clinic IVI Bilbao.

Primary Outcome Measures

Name	Time	Method
Evaluate the percentage of motile sperm adding PRGF versus those samples that growth factors were not added	6 months	Within concerted donor visits in IVI Bilbao will be held: * Removing Blood 9 mL of blood to obtain plasma rich in factors growth; * Seminogram to analyze all semen parameters according to the criteria of the WHO (2010), paying particular attention to sperm motility.; * Sperm vitality will be analyzed before and after treatment with PRGF. PRGF application on the seminal aliquots will be conducted at different concentrations assessing sperm motility.

Trial Locations

Locations (2)

IVI Bilbao; 🇪🇸 Leioa, Vizcaya, Spain

BTI; 🇪🇸 Vitoria, Spain