Comparing protein and mRNA levels in oral precancerous and healthy oral lesion . A study on Oral health risk
Not Applicable
- Conditions
- Health Condition 1: - Health Condition 2: K132- Leukoplakia and other disturbancesof oral epithelium, including tongueHealth Condition 3: K132- Leukoplakia and other disturbancesof oral epithelium, including tongue
- Registration Number
- CTRI/2024/07/071297
- Lead Sponsor
- MGM Dental College and Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Group I (control group)
1. Age and sex matched healthy oral mucosa cases.
2.Normal appearing mucosa of patients who will be undergoing crown lengthening procedure, periodontal surgery or 3rd molar impaction surgery
Group II (study group)
II a. Oral Leukoplakia cases with low-risk epithelial dysplasia
II b. Oral Leukoplakia cases with high risk of epithelial dysplasia
Exclusion Criteria
Group I (control group)
1.Patients not willing to participate in the study.
Group IIa and IIb (study group):
1.Patients with other established carcinomas.
2.Clinico-histopathologically diagnosed OPMDs other than oral leukoplakia
3. Patients who are undergoing any local/systemic treatment for Oral Leukoplakia.
4.Patients not willing to participate in the study.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate Transforming Growth Factor-ß Receptor Type II protein and mRNA expression in low-risk and high-risk Oral Leukoplakia and normal healthy mucosa. <br/ ><br> <br/ ><br>Timepoint: Expected evaluation of the study is 18 months
- Secondary Outcome Measures
Name Time Method To evaluate & compare Transforming Growth Factor-ß Receptor Type II by immunoexpression in low-risk & high-risk Oral Leukoplakia & normal healthy mucosa by qPCR. <br/ ><br> <br/ ><br>Timepoint: Expected Timeline for the evaluation of the study 18 months.