to evaluate effect of nonsurgical periodontal therapy on Vitamin C and total antioxidant levels

Phase 3

Completed

Brief Summary: Primary purpose of the protocol - To Compare the Effects of Non Surgical Periodontal Therapy with and without Vitamin C supplementation on Total Antioxidant Capacity .

Introduction - Chronic Periodontitis is a disease of microbial infection which leads to tissue damage as a result of complex interaction between host immune response.The role of reactive oxygen species have been implicated in periodontal destruction . measurement of total antioxidant capacity will be a representative of total antioxidant capacity of serum and saliva.

Materials and method - 25 healthy subjects will be enrolled in control group

25 chronic periodontitis patients will be enrolled in test group

Test group - it will recieve scaling and root planing and vitamin C supplementation - 500 mg for 3 months

at base line - saliva and serum samples will be taken for both the group for measurement of total antioxidant capacity . at 3 months follow up saliva and serum samples will be re evaluated for test group .

study design - Randomised concurrent parallel controlled trial .

Statistical analysis - descriptive statistics , Independent t test and paired sample t test will be done.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Subjects who are unwilling to give inform consent.
Subjects who are having Systemic diseases or are under regular medications for any systemic diseases.
Subjects who are on Anti-inflammatory/Anti-microbial therapy/mouthwashes or any vitamin supplements in the past 3 months.
Subjects who have undergone Periodontal Therapy in the last 6 months.
Pregnant or Lactating women.
Subjects who give a history of previous or current Smoking.
Subjects with Special Dietary requirements.

Primary Outcome Measures

Name	Time	Method
To Compare the effects of Non Surgical Periodontal Therapy with and without Vitamin C supplementation on Total Antioxidant Capacity	baseline -saliva and serum sample collection \| 2 weeks scaling and root planing completion and Vitamin C-500 mg supplementation for test \| group . \| 3 months - saliva and serum sample collection .

Secondary Outcome Measures

Name	Time	Method
to compare plaque index , gingival index , clinical attachment level before after non surgical periodontal therapy	baseline - saliva and serum sample collection

Locations (1): JSS dental college and hospital
🇮🇳
Mysore, KARNATAKA, India
JSS dental college and hospital
🇮🇳Mysore, KARNATAKA, India
dr swet nisha
Principal investigator
9620947217
swetnisha1@gmail.com