Non-Invasive Oral Biofilm Characterization
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Gingivitis
- Sponsor
- University of California, Irvine
- Locations
- 1
- Primary Endpoint
- Changes in gingival perfusion
- Status
- Withdrawn
- Last Updated
- 3 years ago
Overview
Brief Summary
There is a need for toothpastes that more effectively remove oral plaque and prevent re-formation. The objective of this study is to map the development and resolution of clinical gingivitis using conventional clinical examination and imaging data to determine how useful imaging techniques can be for evaluating how well a toothpaste cleans the teeth
Detailed Description
The researcher can use imaging techniques to map changes in gingival blood flow during the development and resolution of fully reversible, early clinical gingivitis using standard-of-care clinical indices as gold standard The researcher can use imaging techniques to map inflammatory microstructural changes in the oral mucosa including swelling, vasodilation and edema during the development and resolution of fully reversible, early clinical gingivitis using standard-of-care clinical indices as gold standard
Investigators
Beckman Laser Institute and Medical Center
Petra Wilder-Smith, DDS., PhD., Professor, Director of Dentistry
University of California, Irvine
Eligibility Criteria
Inclusion Criteria
- •Adult male or female 18-25 years of age
- •Volunteers with gingivitis but no periodontitis
Exclusion Criteria
- •Subjects who must receive dental treatment during the study dates.
- •History of significant adverse effects following use of oral hygiene products such as toothpastes and mouth rinses. Allergy to personal care/consumer products or their ingredients.
- •Individuals who have taken antibiotics in the previous 3 months
- •Individuals who are pregnant or nursing
Outcomes
Primary Outcomes
Changes in gingival perfusion
Time Frame: up to 6 weeks
optical measurements