NCT01418300已完成4 期
Comparison of Conventional Triple Therapy Versus Sequential Therapy for H. Pylori in Peptic Ulcer Disease: Prospective Randomized Trial
Jun-Won Chung1 个研究点 分布在 1 个国家目标入组 159 人开始时间: 2010年8月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 159
- 试验地点
- 1
- 主要终点
- the eradication rate by urea breath test
研究概览
简要总结
The purpose of this study is to improve first line Helicobacter pylori eradication rate and to compare the sequential versus conventional triple therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •peptic ulcer diseae
- •two test positive rapid urease test, culture, histology
排除标准
- •lactating or pregnant
- •previous stomach surgery
- •severe underlying disease
研究组 & 干预措施
sequential therapy
Active Comparator
first five day amoxicillin+PPI later five day PPI+clarithromycin+metronidazole
干预措施: sequential versus triple (Drug)
conventional triple thearpy
Active Comparator
PPI+amoxicillin+clarithromycin
干预措施: sequential versus triple (Drug)
结局指标
主要结局
the eradication rate by urea breath test
时间窗: 4-6 week later after completion of therapy
to compare the eradication rate (intention-to-treat and per protocol) by urea breath test at least four weeks after treatment
次要结局
未报告次要终点
研究者
Jun-Won Chung
principal investigator
Jeil Pharmacy Co.
研究点 (1)
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