Comparative Effects of High- vs. Moderate Intensity Interval Walking Training on Plasma Volume Variations, Hematological and Muscle-Damage Markers in Overweight/Obese Postmenopausal Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Erythrocytes
研究概览
简要总结
The goal of this clinical trial is to to compare the effects of high (HIIWT) versus moderate-intensity interval walking training (MIIWT) on body composition, plasma volume variations (PVV), hematological parameters, muscle damage and aerobic capacity in overweight/obese postmenopausal women. The main question it aims to answer is:Does HIIWT and MIIWT improve kidney function markers in this population? Researchers will compare HIIWT to MIIWT and to non-training intervention(designed to control group) to see if the training program at different intensities work to improve kidney function markers.
Participants in HIIWT group will: perform a 8-week HIIWT program, three sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 90-110% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in MIIWT group will: perform a 8-week MIIWT program, three sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in control group will : not perform any physical training and maintain their usual daily activities.
详细描述
In obese postmenopausal women, hematological disturbances, reduced plasma volume, and elevated muscle damage biomarkers are associated with impaired oxygen delivery, reduced aerobic capacity, and increased risks of cardiovascular disease, sarcopenia, and functional decline. While responses to exercise are well documented in young healthy individuals, evidence in this high-risk population remains scarce. The purpose is to compare the effects of high (HIIWT) versus moderate-intensity interval walking training (MIIWT) on body composition, plasma volume variations (PVV), hematological parameters, muscle damage and aerobic capacity in overweight/obese postmenopausal women.Thirty-two overweight/obese postmenopausal women were randomly assigned to HIIWT (n = 11), MIIWT (n = 11), or control (CON, n = 10) groups. HIIWT and MIIWT groups performed intermittent walking at 90-110% and 60-80% of the 6-min-walking-test distance, respectively, 3 times/week for 8 weeks (60 min/session). Body composition, hematological and muscle damage markers, and 6 min walk test (6MWT) were assessed pre- and post-intervention. PVV was calculated after eight weeks under third conditions (HIIWT, MIIWT and CON).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 59 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age range of 45-59 years.
- •Postmenopausal women (cessation of menses for at least 12 consecutive months).
- •Body mass index (BMI) ≥ 25 kg/m
- •Body weight remained constant (±2 kg) during the past 3 months.
- •Stable eating habits and physical activity for at least 3 months.
- •Sedentary lifestyle (exercise less than 1h/week).
排除标准
- •Medical contraindications to physical activity, diagnosed metabolic, hormonal, orthopedic, or cardiovascular conditions.
- •Current use of hormone replacement therapy or any prescribed medication.
研究组 & 干预措施
High-intensity intermittent walking training group
performed five 6-minute walking bouts at 90-110% of the 6-minute walking test distance (6MWTD) with 6-min of active recovery between repetitions
干预措施: High intensity interval walking training (Behavioral)
Moderate-intensity intermittent walking training group
repeated five 6-minute walking intervals at 60-80% of 6MWTD interspersed with 6 minutes of active recovery between repetition
干预措施: Moderate-intensity interval walking training (Behavioral)
Control group
No training intervention was intended for the control group.
结局指标
主要结局
Erythrocytes
时间窗: At baseline and at week 9 (after the eight weeks of the training intervention).
Blood levels of erythrocytes were collected from a blood sample (5 ml) and analyzed using a multichannel automated hematology analyzer (XN450; Sysmex, Norderstedt, Germany).
Hemoglobin
时间窗: At baseline and at week 9 (after the eight weeks of the training intervention).
Blood levels of hemoglobin were collected from a blood sample (5 ml) and analyzed using a multichannel automated hematology analyzer (XN450; Sysmex, Norderstedt, Germany).
Hematocrit
时间窗: At baseline and at week 9 (after the eight weeks of the training intervention).
Blood levels of hematocrit were collected from a blood sample (5 ml) and analyzed using a multichannel automated hematology analyzer (XN450; Sysmex, Norderstedt, Germany).
Mean corpuscular volume
时间窗: At baseline and at week 9 (after the eight weeks of the training intervention).
Blood levels of mean corpuscular volume were collected from a blood sample (5 ml) and analyzed using a multichannel automated hematology analyzer (XN450; Sysmex, Norderstedt, Germany).
Mean corpuscular hemoglobin content
时间窗: At baseline and at week 9(after the eight weeks of the training intervention)
Description: Blood levels of mean corpuscular hemoglobin content were collected from a blood sample (5 ml) and analyzed using a multichannel automated hematology analyzer (XN450; Sysmex, Norderstedt, Germany). Time Frame: At baseline and at week 9 (after the eight weeks of the training intervention)
Mean hemoglobin concentration
时间窗: At baseline and at week 9 (after the eight weeks of the training intervention)
Blood levels of mean hemoglobin concentration were collected from a blood sample (5 ml) and analyzed using a multichannel automated hematology analyzer (XN450; Sysmex, Norderstedt, Germany).
Creatine kinase
时间窗: At baseline and at week 9 (after the eight weeks of the training intervention).
Serum concentrations of creatine kinase are measured from a blood sample (5 ml) using a Beckman Coulter AU480 Chemistry Analyzer (France).
Lactate dehydrogenase
时间窗: At baseline and at week 9 (after the eight weeks of the training intervention).
Serum concentrations of lactate dehydrogenase are measured from a blood sample (5 ml) using a Beckman Coulter AU480 Chemistry Analyzer (France).
Plasma volume variations
时间窗: Plasma volume variations (PVV) was calculated after eight weeks under third conditions (High intensity training, Moderate intensity training and No training intervention [control group] ).
Plasma volume variations (PVV) was calculated based on measured hematocrit (Ht) and hemoglobin (Hb) values according to the method developed by Dill and Fink (1974). %PVV=100 ×\[(Hb0/Hb1) ×(100 - Ht1) / (100 - Ht0)\] - 1, where 0 is the value measured before training program and 1 is the value measured after training program.
Body weight
时间窗: At baseline and after eight weeks of the training intervention.
Body weight (kg) was recorded , with barefoot and lightly dressed subjects, using an electronic scale (Tanita BC-533, Tokyo, Japan).
Height
时间窗: At baseline and at week 9 (after the eight weeks of the training intervention).
Height (m) was determined using a standard stadiometer (Holtain Ltd., UK).
Body fat
时间窗: At baseline and at week 9 (after the eight weeks of the training intervention).
Body fat (%) was recorded using an electronic scale (Tanita BC-533, Tokyo, Japan).
Body mass index
时间窗: At baseline and at week 9 (after the eight weeks of the training intervention).
Body mass index (kg/m²) was calculated as weight (kg) divided by height squared (m²).
Waist circumference
时间窗: At baseline and at week 9 (after the eight weeks of the training intervention).
Waist circumference (cm) was measured to the nearest 0.1 cm using a non-deformable anthropometric tape, placed horizontally at the midpoint between the inferior margin of the last palpable rib and the superior border of the iliac crest, with the participant standing upright and breathing normally.
次要结局
未报告次要终点
研究者
Wissal Abassi
Principal Investigator
High Institute of Sports and Physical Education of Kef