Study on the correlation between the common TCM syndromes of gout and intestinal flora

Phase 1

Recruiting

• Conditions: Gout

• Registration Number: ITMCTR2100005378
• Lead Sponsor: Yunnan Hospital of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion criteria of case group :(1) meet the diagnostic criteria of primary gout; (2) TCM syndrome differentiation belongs to damp-heat accumulation type or spleen deficiency dampness resistance type; (3) 18-70 years old; (4) Voluntarily participate in the study and sign the informed consent to enter the clinical study; (5) No gastrointestinal diseases, no antibiotics, gastrointestinal drugs or probiotics in the past 2 months;
Control group inclusion criteria :(1) non-gout and hyperuricemia; (2) Exclude metabolic diseases, such as diabetes, obesity and hyperlipidemia; (3) No gastrointestinal diseases, no antibiotics, gastrointestinal motility drugs or probiotics in the past 2 months; (4) 18-70 years old; (5) As far as possible from the same region as the case group.

Exclusion Criteria

(1) those who have taken antibiotics, probiotics and prebiotics within 2 weeks;(2) Secondary hyperuricemia and gout, such as congenital metabolic disease, myeloproliferative disease, advanced hypertension, diabetic ketoacidosis caused by hyperuricemia, renal failure, tumor chemotherapy and/or radiotherapy, etc.;(3) arthropathy caused by rheumatoid arthritis, suppurative arthritis, traumatic arthritis, psoriatic arthritis, pseudogout, lupus erythematosus and other diseases;(4) Blood creatinine = 133umol/ L;(5) patients with major organ failure or mental illness, tumor and other diseases;(6) Bmi = 50 or alcoholics;(7) pregnant and lactating women;(8) Exclude metabolic diseases, especially those affecting intestinal flora;(9) persons under the age of 18 or over 70;

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Routine stool + occult blood test;kidney function (BUN, Cr, UA);urine routine;Tenderness score;Blood Routine Examination;CRP;lesion site X film;electrocardiogram;ESR;blood glucose;Blood lipid;TCM syndrome score;Liver function (ALT, AST);Intestinal flora detection;