Control of heart rhythm by the brain: the impact of stress-induced reductions in amygdala and hippocampus GABA activity on cardiac electrophysiology (BrainBeatS)
Withdrawn
- Conditions
- stress and the brainsudden cardiac death (SCD)10019280
- Registration Number
- NL-OMON46454
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 25
Inclusion Criteria
- Male
- Age 20-35 years
- no heart and vascular disease history
- no psychiatric disorder history
Exclusion Criteria
- General contraindications for MRI (such as claustrophobia)
- heart and vascular disease history
- psychiatric disorder history
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>o ECG markers of ANS control: heart rate (HR), heart rate variability (HRV)<br /><br>o Concentrations of GABA and glutamate in amygdala and hippocampus </p><br>
- Secondary Outcome Measures
Name Time Method <p>o Stress markers: The State-Trait Anxiety Inventory (STAI), Perceived Stress<br /><br>Reactivity Scale (PRSR), Barratt Impulsiveness Scale (BIS), life event<br /><br>questionnaire, saliva biomarkers of stress (cortisol) and catecholamines<br /><br>(alpha-amylase10), blood pressure<br /><br>o Amygdala and hippocampus connectivity after the SECPT and control condition<br /><br>(fMRI).</p><br>