Multiple Sclerosis - Inflammatory, Neurological and Muscular Adaptations to Progressive Resistance Training
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 4
- 主要终点
- Blood-borne biomarkers
研究概览
简要总结
The purpose of this study is to investigate underlying mechanisms possibly explaining the beneficial effects of progressive resistance training for people with multiple sclerosis.
详细描述
Exercise in general, and progressive resistance training (PRT) in particular, is regarded as an important tool in the rehabilitation of people with multiple sclerosis (MS).
Previous studies have reported positive effects of PRT on muscle strength, functional capacity, fatigue and quality of life. Also, a possible disease modifying effect has been proposed. However, the underlying physiological mechanisms that might explain these beneficial effects and the possible effects on disease progression are unresolved. Additionally, none of the previous studies has been concerned with the possible impact of MS progression type, gender and/or medication.
The purpose of this randomized, controlled, gender stratified trial is to investigate underlying mechanisms possibly explaining the beneficial effects of progressive resistance training for people with multiple sclerosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed relapsing-remitting MS according to the McDonald criteria
- •Expanded Disability Status Scale (EDSS) between 2.0 and 5.5
- •Be able to train twice a week at the University
- •Use interferon based medication
排除标准
- •Alcohol abuse, Alzheimer's and pacemaker (or other metallic implant)
- •Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases
- •Having had an attack in a period of 8 weeks prior to the start of the intervention period
- •Having an attack during the intervention period
- •Pregnancy
- •Systematic resistance training in a period of 3 months prior to the start of the intervention period.
- •Training adherence of less than 85%.
结局指标
主要结局
Blood-borne biomarkers
时间窗: Change from baseline to 24 weeks
Resting levels of bloodbourne biomarkers; * Cytokines * Neurotrophins
次要结局
- Brain volume(Change from baseline to 24 weeks)
- Walking performance(Change from baseline to 24 weeks)
- Self-reported measures(Change from baseline to 24 weeks)
- Body Composition(Change from baseline to 24 weeks)
- Neuro-muscular function of knee extensors(Change from baseline to 24 weeks)
- Thigh muscle cross-sectional area(Change from baseline to 24 weeks)