Multiple Sclerosis and Muscle Function - Effects of Heavy Progressive Resistance Training
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- University of Aarhus
- Enrollment
- 36
- Locations
- 2
- Primary Endpoint
- Muscle strength (isokinetic testing)
- Status
- Completed
- Last Updated
- 17 years ago
Overview
Brief Summary
The purpose of the present investigation is to determine whether MS patients can tolerate and benefit from heavy progressive resistance training. A second purpose is to determine both neural and muscle morphological adaptations to heavy progressive resistance training.
Detailed Description
Multiple sclerosis (MS) patients are characterized by reduced muscle strength and functional capacity. For MS patients, improvements in muscle strength and thereby functional capacity, would have the potential to make both the daily living easier and to extend the time living independently. Attempts to improve muscle strength and function include the application of physical training, although the general advice to MS patients for many years has been to avoid participation in physical training. It has now been demonstrated that endurance training at low to moderate intensity is well tolerated by MS patients, but it only induces modest improvements in both muscle strength and functional capacity. Heavy progressive resistance training (HPRT) has proven to be the most effective means to improve muscle strength and functional capacity during daily activities in healthy older people. However, the effects of HPRT have not been investigated in randomised control trials in MS patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of Relapsing Remitting Multiple Sclerosis according to the McDonald criteria
- •Expanded Disability Status Scale Score between 3,0-5,5
- •Be able to walk at least 100m
- •Be able to train twice a week at the University
Exclusion Criteria
- •Alcohol abuse, Alzheimer's and pacemaker
- •Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases
- •Having had an attack in a period of 8 weeks prior to the start of the intervention period
- •Having an attack during the intervention period
- •Pregnancy
- •Systematic resistance training in a period of 3 months prior to the start of the intervention period.
- •Training adherence of less than 85%.
Outcomes
Primary Outcomes
Muscle strength (isokinetic testing)
Time Frame: Before and after the intervention
Secondary Outcomes
- Muscle biopsies from m. vastus lateralis(Before and after the intervention)
- HRQOL: SF36(Before and after the intervention)
- Blood samples (immunologic parameters)(Before and after the intervention)
- Depression: Major Depression Inventory (MDI)(Before and after the intervention)
- Surface EMG from m. vastus lateralis during MVC(Before and after the intervention)
- Fatigue (Fatigue Severity Scale - FSS, Modified Fatigue Inventory - MFI-20)(Before and after the intervention)
- Functional capacity (Six minute walk test, 10m walk test, chair rise, stair climbing)(Before and after the intervention)
- % Fat (skinfold)(Before and after the intervention)