Multiple Sclerosis and Heavy Progressive Resistance Training

Not Applicable

Completed

• Conditions: Multiple Sclerosis
• Interventions: Behavioral: Resistance training

• Registration Number: NCT00381576
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose of the present investigation is to determine whether MS patients can tolerate and benefit from heavy progressive resistance training. A second purpose is to determine both neural and muscle morphological adaptations to heavy progressive resistance training.

Detailed Description

Multiple sclerosis (MS) patients are characterized by reduced muscle strength and functional capacity. For MS patients, improvements in muscle strength and thereby functional capacity, would have the potential to make both the daily living easier and to extend the time living independently. Attempts to improve muscle strength and function include the application of physical training, although the general advice to MS patients for many years has been to avoid participation in physical training. It has now been demonstrated that endurance training at low to moderate intensity is well tolerated by MS patients, but it only induces modest improvements in both muscle strength and functional capacity. Heavy progressive resistance training (HPRT) has proven to be the most effective means to improve muscle strength and functional capacity during daily activities in healthy older people. However, the effects of HPRT have not been investigated in randomised control trials in MS patients.

Study Timeline

• Study First Submitted: 2006-09-27
• Study First Submitted QC: 2006-09-27
• Study First Posted: 2006-09-28
• Study Start: 2006-11
• Primary Completion: 2008-03
• Study Completion: 2008-06
• Status Verified: 2008-08
• Last Update Submitted: 2008-08-11
• Last Update Posted: 2008-08-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Clinical diagnosis of Relapsing Remitting Multiple Sclerosis according to the McDonald criteria
• Expanded Disability Status Scale Score between 3,0-5,5
• Be able to walk at least 100m
• Be able to train twice a week at the University

Exclusion Criteria

• Alcohol abuse, Alzheimer's and pacemaker
• Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases
• Having had an attack in a period of 8 weeks prior to the start of the intervention period
• Having an attack during the intervention period
• Pregnancy
• Systematic resistance training in a period of 3 months prior to the start of the intervention period.
• Training adherence of less than 85%.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
A	Resistance training	12 weeks of resistance training

Primary Outcome Measures

Name	Time	Method
Muscle strength (isokinetic testing)	Before and after the intervention

Secondary Outcome Measures

Name	Time	Method
Depression: Major Depression Inventory (MDI)	Before and after the intervention
Fatigue (Fatigue Severity Scale - FSS, Modified Fatigue Inventory - MFI-20)	Before and after the intervention
% Fat (skinfold)	Before and after the intervention
HRQOL: SF36	Before and after the intervention
Muscle biopsies from m. vastus lateralis	Before and after the intervention
Blood samples (immunologic parameters)	Before and after the intervention
Surface EMG from m. vastus lateralis during MVC	Before and after the intervention
Functional capacity (Six minute walk test, 10m walk test, chair rise, stair climbing)	Before and after the intervention

Trial Locations

Locations (2)

MS Clinic, Department of Neurology, Aarhus University Hospital; 🇩🇰 Aarhus, Denmark

Department of Sports Science, University of Aarhus; 🇩🇰 Aarhus, Denmark