Tremor in demyelinating neuropathy, a study on the prevalence, etiology and characteristics of tremor in demyelinating neuropathy

Recruiting

• Conditions: tremor in demyelinating neuropathy; tremor associated with polyneuropathy; 10028037

• Registration Number: NL-OMON54557
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 260

Inclusion Criteria

Patients with demyelinating neuropathy with and without tremor
1) CIDP
For the diagnosis CIDP we will use the EFNS/PNS criteria for the diagnosis of
CIDP. In addition we will include patients fulfilling the clinical criteria and
at least two supportive criteria (24).
2) IgM paraproteinemic neuropathy
Patients with chronic distal polyneuropathy with either axonal or demyelinating
characteristics and presence of monoclonal IgM antibodies (24).
3) CMT-1A and CMT-1B
Patients with uniform demyelinating polyneuropathy, genetically confirmed in
patient or in a first degree relative.

Patients with axonal neuropathy with and without tremor
- EMG confirmed axonal polyneuropathy according to EMG examination in Amsterdam
UMC or patients clinically diagnosed with a chronic axonal polyneuropathy
during an outpatient clinic visit at the AMC, without an EMG examination. These
patients will be included by searching electronic health records in the time
frame of January 1st until December 31st 2017;
- the etiology of the neuropathy is either diabetes mellitus, chronic
idiopathic axonal polyneuropathy (CIAP) or medication induced (provided the
causative drug cannot induce tremor) according to the last diagnosis registered
and is not associated with demyelinating disorders;
- neuropathy with a chronic course (symptoms for over 3 months).

Additional inclusion criteria that apply to all groups above:
- age >=18 years
- informed consent

Exclusion Criteria

- insufficient knowledge of the Dutch language
- inability to visit the hospital

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the prevalence of tremor in demyelinating<br /><br>neuropathy and the tremor characteristics. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Association between presence of tremor and tremor severity with increase in<br /><br>functional disability and decrease in quality of life in patients with<br /><br>neuropathy, after correction for other impairment modalities such as sensory<br /><br>impairment and muscle weakness.<br /><br>- Changes in tremor severity, impairment and functioning during follow-up.<br /><br>- Explorative anaylsis of clinical, laboratory, fMRI and neurophysiological and<br /><br>fMRI characteristics of patients with tremor and patients without tremor to<br /><br>further elucidate the pathophysiology of tremor in demyelinating<br /><br>polyneuropathie.<br /><br>- The difference in prevalence between patients with demyelinating<br /><br>polyneuropathy and axonal polyneuropathy.</p><br>