The influence of stress on Parkinson's tremor

Phase 2

Completed

• Conditions: Parkinson's disease; Nervous System Diseases; Parkinson disease

• Registration Number: ISRCTN89589002
• Lead Sponsor: Radboud University Nijmegen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-09-06
• Study Start: 2021-12-10
• Last Update Posted: 4 September 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

1. Idiopathic Parkinson’s disease according to UK brain bank criteria
2. Age range: 18-80 years
3. Tremor-dominant group: the presence of clear resting tremor for at least one arm (defined as a resting tremor score of =2 MDS-UPDRS points)
4. Non-tremor group: absence of clear resting and postural tremor

Exclusion Criteria

1. Neuropsychiatric co-morbidity
2. Contraindications for MRI scanning (e.g. pacemaker, implanted metal parts, deep brain stimulation, claustrophobia)
3. Cardiac arrhythmias (in patient history or visible on ECG)
4. Contraindications for beta-blockers (e.g. bradycardia, peripheral circulation disturbances, asthma or obstructive lung disease, hypotension)
5. Use of medication that may interact with propranolol
6. Use of medication that inhibits relevant CYP enzymes that are involved in metabolizing propranolol
7. Severe head tremor or dyskinesias
8. Cognitive impairment (Mini-Mental State Exam [MMSE] <26)
9. Parkinson disease duration >10 years, severe ON/OFF medication fluctuations, or daily Levodopa-equivalent dose >1200 mg

Study & Design

• Study Type: Interventional
• Study Design: Not specified