Changes of the Neuronal Activity in the Subthalamic Nucleus Under Propofol Sedation During Stereotactic Electrode Implantation.
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Changes in the electrical activity of neuron cells of the basal ganglia in the examined patients
Study Overview
Brief Summary
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
Detailed Description
Deep Brain Stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who have to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the Basal Ganglia.
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to propofol sedation. Electrical activity of single neurons will be recorded before and after sedation.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Candidate for Deep Brain Stimulation Surgery.
- •Informed concent obtained.
Exclusion Criteria
- •Suspected difficult intubation (by history or physical examination).
- •Allergy to Propofol, eggs or soy-beans.
- •History of sleep apnea syndrome.
Outcomes
Primary Outcomes
Changes in the electrical activity of neuron cells of the basal ganglia in the examined patients
Time Frame: Within 24 hours needed to analyse the data
Secondary Outcomes
No secondary outcomes reported