Effects of platelet concentrate (ALB-PRF) on bone healing when placed in immediate dental implant

Not yet recruiting

• Conditions: Procedure and treatment not carried out for other reasons,

• Registration Number: CTRI/2025/04/084967
• Lead Sponsor: ITS DENTAL College

Brief Summary

This study helps to find the effectiveness of ALB-PRF in promoting bone formation when placed in immediate dental implants.

In dental implants osseointegration and implant stability is prime concern and to enhance these bone grafts and blood concentrates are widely used.

Albumin-enriched biomaterials provide an optimal structure for cell proliferation and show minimal reduction over time, suggesting less in vitro degradation. Studies further suggest that the association with albumin can stabilize the fibrin network’s ultrastructure. In addition, preliminary data indicate that combining denatured serum albumin significantly enhances the PRF-based scaffold, yielding an autologous, biocompatible material with the potential enhance durability and sustained action.Additionally they release higher level of growth factors which enhance their therapeutic potential.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-04-30
• Last Update Posted: 2025-11-04

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients between 30 and 60 years of age, having a hopeless mandibular tooth indicated for extraction (due to an unrestorable fracture or a carious lesion) requiring immediate dental implant placement.
• The absence of any active infection, pus discharge and bone dehiscence on buccal wall of tooth socket.
• Intact socket walls.
• ASA Grade I and II.

Exclusion Criteria

Aggressive periodontitis Medically compromised patients External root resorption Tobacco users Pregnant women.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ALB-PRF is effective in promoting bone formation	ALB-PRF is effective in promoting bone formation in 8 weeks

Secondary Outcome Measures

Name	Time	Method
ALB-PRF is effective in enhancing implant stability	ALB-PRF is effective in enhancing implant stability in

Trial Locations

Locations (1)

ITS Dental College Hospital and Research Centre; 🇮🇳 Nagar, UTTAR PRADESH, India

ITS Dental College Hospital and Research Centre

🇮🇳Nagar, UTTAR PRADESH, India

Dr Antriksh Sharma

Principal investigator

8716069310

antrikshshar@gmail.com