Correlation Between Coronary and Carotid Atherosclerotic Disease (CAD) and Links With Clinical Outcomes

Completed

• Conditions: Atherosclerosis

• Registration Number: NCT01353612
• Lead Sponsor: Canadian Atherosclerosis Imaging Network

Brief Summary

This is a prospective, multi-center imaging study expecting to enroll approximately 1350 patients scheduled for clinically-indicated coronary angiography. Following informed consent, patient will undergo baseline coronary intravascular ultrasound (IVUS) imaging and non-invasive ultrasound imaging of their carotid arteries. Following a 2-year follow-up period, patients will undergo repeat coronary IVUS and standard invasive coronary angiography as well as carotid ultrasound examination.

Additionally, patients will be contacted by phone on an annual basis for 5 years to collect cardiovascular and cerebrovascular clinical endpoints. Evaluations of plaque burden will be made using invasive and non invasive imaging tools in order to assess correlations between vascular beds, imaging technologies and main cardiovascular events.

Detailed Description

CTA and PET Substudy:

A subset of patients enrolled into the main CAIN3 study will undergo a CTA. At sites where both CTA and PET imaging modalities exist, patients will be asked to undergo both tests. The CTA and PET scans can be done separately on 2 imaging beds on different days or performed on the same imaging bed, resulting in a combined CTA and PET scan being done in one scheduled visit. All imaging will be done within 90 days after the follow up IVUS.

The choice of radiotracer used (NaF or FDG) for PET imaging will be dependent upon site and availability on the day of the scan. A total of 120 patients will be enrolled in this substudy with approximately 50-60 undergoing CTA and PET.

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2011-05-12
• Study First Submitted QC: 2011-05-12
• Study First Posted: 2011-05-13
• Primary Completion: 2017-12
• Study Completion: 2017-12
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-20
• Last Update Posted: 2020-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1626

Inclusion Criteria

• Male and female patients over the age of 18 years.
• Patients scheduled for clinically indicated coronary angiography and possible ad hoc percutaneous coronary intervention (PCI) will be evaluated before their scheduled procedure.
• Written informed consent (approved by the Institutional Review Board [IRB]/Independent Ethics Committee [IEC]) obtained prior to any study specific procedures.
• Patients considered to be stable at enrollment (at the discretion of the investigator) are eligible provided they meet all other entry criteria.
• Angiogram meeting qualifying criteria

Exclusion Criteria

• Women of childbearing potential (women who are not surgically sterile or postmenopausal defined as amenorrhea for >12 months) who refuse to undergo a urine or serum pregnancy test immediately prior to baseline and repeat imaging evaluations The urine or serum pregnancy test must be negative prior to imaging evaluations.
• Previous coronary artery bypass graft (CABG) surgery or probable need for CABG in the next 24 months.
• Patients who have symptomatic congestive heart failure (CHF) (New York Heart Association [NYHA] Class III or IV) at baseline.
• Patients with clinically significant valvular heart disease likely to require surgical repair or replacement during the treatment period of the study
• Any clinically significant medical condition or presence of any laboratory abnormality that is considered by the investigator to be clinically important and could interfere with the conduct of the study.
• The presence of severe liver disease as defined by the presence of cirrhosis, chronic active hepatitis, or chronic jaundice with hyperbilirubinemia,
• Patients with eGFR < 45 ml/min prior to baseline imaging procedures, or with nephrotic syndrome
• Patients with a life expectancy less than 2 years.
• History of malignancy (except for curatively treated basal cell or squamous cell carcinoma of the skin) during the 3 years prior to the screening.
• Unable or unwilling to comply with protocol requirements, or deemed by the investigator to be unfit for the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
co-primary outcome measure - Nominal change from baseline in percent atheroma volume	2 years	intravascular ultrasound measure
co-primary outcome measure - nominal change from baseline in carotid IMT	2 years	2D B-mode carotid ultrasound measure

Secondary Outcome Measures

Name	Time	Method
cardiovascular morbidity and mortality	5 years	as adjudicated by a Clinical Endpoint Committee

Trial Locations

Locations (38)

Royal Alexandra Hospital; 🇨🇦 Edmonton, Alberta, Canada

University of Alberta Hospital; 🇨🇦 Edmonton, Alberta, Canada

Foothills Medical Centre; 🇨🇦 Calgary, British Columbia, Canada

Royal Columbian Hospital; 🇨🇦 New Westminster, British Columbia, Canada

Vancouver General Hospital; 🇨🇦 Vancouver, British Columbia, Canada

Interventional Cardiology Research, St. Paul's Hospital; 🇨🇦 Vancouver, British Columbia, Canada

Victoria Heart Institute Foundation; 🇨🇦 Victoria, British Columbia, Canada

John Health Science Center; 🇨🇦 St John's, Newfoundland and Labrador, Canada

Queen Elizabeth II - Health Sciences Centre; 🇨🇦 Halifax, Nova Scotia, Canada

Cambridge Cardiac Care; 🇨🇦 Cambridge, Ontario, Canada

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