A Prospective Natural History Study of Carotid Atherosclerosis
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 700
- Locations
- 1
- Primary Endpoint
- To detect if carotid ultrasound and carotid microwave radiometry measurements can predict the incidence of cerebrovascular and cardiovascular events in patients with coronary artery disease
Study Overview
Brief Summary
A prospective study of 700 patients with coronary artery disease will undergo non invasive evaluation of their carotid arteries by ultrasound and microwave radiometry. The patients will be followed up for 3 years and their outcome regarding the cardiovascular events (death, cardiac events, cerebrovascular events) will be recorded
Detailed Description
Carotid artery Thermal heterogeneity recorded by MR will be corelated to cardiovascular events (death, cardiac events, cerebrovascular events) as well as to all demographic (age, sex, hypertension, dyslipidemia, smoking status, etc) factors
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 30 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Consecutive patients with coronary artery disease admitted in our hospital
Exclusion Criteria
- •Patients with history of previous cerebrovascular event,
- •History of vasculitis, intermittent inflammatory, infectious, or neoplastic conditions likely to be associated with an acute-phase response.
Outcomes
Primary Outcomes
To detect if carotid ultrasound and carotid microwave radiometry measurements can predict the incidence of cerebrovascular and cardiovascular events in patients with coronary artery disease
Time Frame: 3 years
Microwave radiometry is a non invasive and safe technique that measures temperature of the internal tissues by detecting the normal radiation of the tissues in microwave frequencies. The primary outcome of the study is to see if the temperatures measured in the carotid arteries of patients with coronary artery disease can predict their outcome regarding cerebrovascular and cardiovascular events
Secondary Outcomes
- Relation of other demographic factors with carotid ultrasound and microwave radiometry measurements and outcome(3 years)
Investigators
Konstantinos Toutouzas
Associate Professor of Cardiology
National and Kapodistrian University of Athens