Natural History of Carotid Atherosclerosis

• Conditions: Carotid Artery Disease; Angina Pectoris; Stroke; Myocardial Infarction

• Registration Number: NCT01521351
• Lead Sponsor: National and Kapodistrian University of Athens

Brief Summary

A prospective study of 700 patients with coronary artery disease will undergo non invasive evaluation of their carotid arteries by ultrasound and microwave radiometry. The patients will be followed up for 3 years and their outcome regarding the cardiovascular events (death, cardiac events, cerebrovascular events) will be recorded

Detailed Description

Carotid artery Thermal heterogeneity recorded by MR will be corelated to cardiovascular events (death, cardiac events, cerebrovascular events) as well as to all demographic (age, sex, hypertension, dyslipidemia, smoking status, etc) factors

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-01-25
• Study First Submitted QC: 2012-01-27
• Study First Posted: 2012-01-30
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-04
• Last Update Posted: 2019-09-06
• Primary Completion: 2020-06
• Study Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 700

Inclusion Criteria

• Consecutive patients with coronary artery disease admitted in our hospital

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Exclusion Criteria

• Patients with history of previous cerebrovascular event,
• History of vasculitis, intermittent inflammatory, infectious, or neoplastic conditions likely to be associated with an acute-phase response.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To detect if carotid ultrasound and carotid microwave radiometry measurements can predict the incidence of cerebrovascular and cardiovascular events in patients with coronary artery disease	3 years	Microwave radiometry is a non invasive and safe technique that measures temperature of the internal tissues by detecting the normal radiation of the tissues in microwave frequencies. The primary outcome of the study is to see if the temperatures measured in the carotid arteries of patients with coronary artery disease can predict their outcome regarding cerebrovascular and cardiovascular events

Secondary Outcome Measures

Name	Time	Method
Relation of other demographic factors with carotid ultrasound and microwave radiometry measurements and outcome	3 years

Trial Locations

Locations (1)

First Department of Cardiology, University of Athens, Medical School. Hippocratio Hospital; 🇬🇷 Athens, Attiki, Greece