Chongqing Primary Aldosteronism Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- numbers of patients who develop cardiovascular events
研究概览
简要总结
We intends to conduct a series of original clinical research about PA, and establish a large cohort of PA and essential hypertension patients with long-term follow-up of cardiovascular events, renal end points etc. We will establish a large sample of blood, urine, adrenal tissue of the subjects, and the genomics,metabonomics, proteomics database, to explore the mechanism of the PA and target organ damage, risk factors, diagnostic methods and biomarkers.
详细描述
This study will include the subjects of a series of studies on hypertension conducted by our team, including essential hypertension, PA subjects, and establish a large sample database and specimen bank through follow-up and omics analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hypertensive patients who completed ARR screening and necessary further tests;
- •Voluntary to sign the informed consent.
排除标准
- •patients with severe cardiac, hepatic or renal dysfunction;
- •suspicious or confirmed other types of secondary hypertension, including Cushing's syndrome, pheochromocytoma and renal artery stenosis et al.
结局指标
主要结局
numbers of patients who develop cardiovascular events
时间窗: 1-15 years
compare the long-term cardiovascular and cerebrovascular events in patients with primary aldosteronism and essential hypertension
次要结局
- Cardiovascular risk score(1-15 years)
- estimated glomerular filtration rate (eGFR)(1-15 years)
- subgroup analysis of cardiovascular events(1-15 years)
- quality of life score(1-15 years)
- The incidence of left ventricular hypertrophy(1-15 years)
- the variation of carotid intima-media thickness(1-15 years)
- The incidence of new atrial fibrillation(1-15 years)
研究者
Qifu Li
Director of endocrinology
First Affiliated Hospital of Chongqing Medical University