Causative Diagnosis on Prosthetic Joint Infections: Establishment of a Comprehensive Diagnostic Strategy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Prosthetic Joint Infections
- Sponsor
- Assistance Publique Hopitaux De Marseille
- Enrollment
- 980
- Locations
- 1
- Primary Endpoint
- Bone biopsies multisite
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
On joint orthopaedic hardware infections are one of the most frequently encountered complications in orthopaedic surgery. However 6% of the cultures remain sterile, etiological diagnosis cannot be established despite obvious signs of infection. As part of this research project, we have developed a new strategy diagnosis including directly the use of PCR to reduce the number of negative results. This should have a major therapeutic impact in terms of timeliness and specificity of antibiotic.
Primary:
Evaluate the effectiveness of the new diagnostic strategy on etiological identification of prosthesis infections.
Hypothesis:
Minimum 6 percent increase in the number of patients with an etiological diagnosis of infection on prosthesis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient is more than 18 years old.
- •Patient with a prescription of a microbiologic diagnostic of Prosthetic joint infection
- •Patient who do not declined to have his medical records reviewed for research
- •Patient with health insurance
Exclusion Criteria
- •Patient minor (\<18 years).
- •Pregnant or lactating woman.
- •Major under guardianship Patient.
- •Patient deprived of liberty or under court order
Outcomes
Primary Outcomes
Bone biopsies multisite
Time Frame: 4 years
Increase of at least 6% of patients with an etiologic diagnosis of prosthesis infection established.