Diagnosis of Periprosthetic Joint Infection and the Common Pathogens, Durg-resistance in Periprosthetic Joint Infection
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Arthropathy of Hip
- Sponsor
- Peking University People's Hospital
- Enrollment
- 160
- Primary Endpoint
- Evaluation the specific and sensitivity of CRP
- Last Updated
- 8 years ago
Overview
Brief Summary
This retrospective study aims to improve the diagnosis of PJI as well as to identify microorganisms causing periprosthetic joint infection (PJI) and the drug-resistant spectrum
Detailed Description
160 patients who underwent revision or re-revision total hip or knee arthroplasty for different reasons in our institution were recruited from August 2013 to August 2016. 80 patients meet the criteria of PJI from the muscle and skeletal muscle Association (MSIS) are divided to the infection group, another 80 patients are divided into the non-infection group. Medical and demographic data were recorded. Collected lab examinations included blood routine test, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), synovial leukocyte counts, Receiver Operating Characteristic Curve-Area Under Curve (ROC-AUC) analysis will be used to evaluate the specific and sensitivity of diagnosis index. Moreover,microorganisms isolated from periprosthetic tissues and articular fluid. Postoperatively, the prosthesis was sent for ultrasound sonication. The sonicate extraction, implant surrounding tissue and synovium were sent for microbiologic culture, and the implant-surrounding-tissue were also sent for pathological examination. The isolated strains and drug-resistance rate for each bacterium for different antibiotics were presented.
Investigators
Lin Jianhao
The clinical professor of arthritis clinic and research center
Peking University People's Hospital
Eligibility Criteria
Inclusion Criteria
- •patient who underwent revision or re-revision total hip or knee arthroplasty for different reasons in our institution
Exclusion Criteria
- •Patients who refused to join the trial group;
- •Revision total hip/knee replacement for periprosthetic fracture;
- •patients who missed some of important examination;
- •Revision total hip/knee replacement for metal sensitivity;
- •Revision total hip/knee replacement for the last period of second-stage revision;
- •Patient who underwent revision with RA or other inflammatory disease.
Outcomes
Primary Outcomes
Evaluation the specific and sensitivity of CRP
Time Frame: within 4 weeks before the operation
To test the specifity and sensitivity of CRP
Evaluation the specific and sensitivity of synovial leukocyte counts
Time Frame: within 4 weeks before the operation
To test the specifity and sensitivity of synovial leukocyte counts
Evaluation the specific and sensitivity of ESR
Time Frame: within 4 weeks before the operation
To test the specifity and sensitivity of ESR
Secondary Outcomes
- Drug-resistant spectrum.(within 4 weeks before the operation)
- Microorganisms identification and the(within 4 weeks before the operation)