Mortality and Neurologic Complications Associated With Rapid Versus Slow Correction of Hyponatremia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,037
- 试验地点
- 1
- 主要终点
- In-Hospital Mortality
研究概览
简要总结
This study examines the impact of different rates of sodium correction on the outcomes of patients with severe hyponatremia (serum sodium ≤ 120 mEq/L). Hyponatremia is a condition where blood sodium levels are dangerously low, and its treatment must be carefully managed to avoid complications. Standard guidelines recommend correcting sodium levels slowly to prevent a rare but serious neurological condition called osmotic demyelination syndrome (ODS). However, recent evidence suggests that a faster rate of sodium correction may reduce hospital stay length and mortality without increasing the risk of ODS.
This retrospective study, conducted from 2010 to 2023 at a hospital in Buenos Aires, Argentina. It compares the outcomes of patients who had their sodium levels corrected rapidly (≥ 8 mEq/L in 24 hours) to those who had slower corrections. The primary outcomes measured are mortality and the development of ODS.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 18 years or older.
- •First hospitalization at Hospital Italiano de Buenos Aires with a serum sodium (natremia) level ≤ 120 mEq/L at admission.
排除标准
- •Absence of serum sodium values after the first 24 hours of hospitalization.
- •Hospitalizations shorter than 24 hours.
- •Patients with previous hospitalizations prior to the study period where admission serum sodium levels were ≤ 120 mEq/L.
结局指标
主要结局
In-Hospital Mortality
时间窗: From hospital admission to discharge or death. To evalute in-Hospital mortality we will use logistic regression, not time to event analysis.
In-Hospital Mortality refers to the occurrence of death from any cause during a patients hospital stay. In the context of this study, it specifically measures the rate at which patients with severe hyponatremia (serum sodium ≤ 120 mEq/L) die before being discharged from the hospital.
次要结局
- 30-Day Mortality(From the date of hospital admission up to 30 days. From hospital admission to discharge or death. To evalute 30-Day mortality we will use logistic regression, not time to event analysis.)
- Length of stay(From the date of hospital admission to the date of discharge)
- Incidence of Osmotic Demyelinitation Syndrome (ODS)(From the date of hospital admission through hospital discharge, up to 180 days.)
研究者
ANACLARA MURUJOSA
Principal Investigator
Hospital Italiano de Buenos Aires